Preclinical efficacy experiments testing sunitinib in animal cancer models display a lack of methodological rigour, with trim-and-fill analysis suggesting prominent publication bias that leads to an overestimation of treatment effect.
Animal studies of fatty liver disease over-estimate the benefit of drugs due to publication bias and are confounded by off-target weight loss, illustrating the challenge of successful translational across species.
Identification and functional characterization of the first non-chordate kisspeptin neuropeptide system in the sea cucumber indicates the ancient origin of the intracellular signaling and physiological functions of this molecular system.
A multi-cohort analysis of 2,500 gut microbiomes and five major diseases discovers that disease-microbiome associations display specific age-centric trends, with diseases characterized by age-centric trends of species gain/loss.
The animal phylogeny of glutamate receptors indicates that vertebrate types do not account for all receptor classes originated during evolution, neither are they the pinnacle of a linear evolutive process.
Nationally-representative verbal autopsies can be linked to seasonal patterns, clinical syndromes, and climate regions to describe novel insights regarding the microbiologic etiologies of childhood pneumonia and diarrhea in India.