The discontinuous speed of transcription enables riboswitch molecules to adopt meta-stable structures in response to the presence of their cognate ligand, thereby gene-regulation by means of structure induced transcription termination can occur.

Molecular insights to phytochrome activation and signal transduction over long distances enable the allosteric regulation of enzymatic effectors.

A human psychopharmacology study reveals that a drug that affects the dopamine and noradrenaline systems enhances people's ability to adapt their learning rate to suit the volatility of the environment.

Multimodal spectroscopy (smFRET, EPR, SAXS, and SANS) and integrative structural modeling reveal large-scale domain rearrangements in human guanylate binding protein 1 (hGBP1) that are driving forces for the formation of oligomers that enable its biological function in innate immune defense.

Through a single mutation at position 188, vertebrate rhodopsin acquires the ability to recover the dark state from the active state by a thermal reaction and by a photoreaction.

A cryptic pocket in the myosin motor domain selectively opens in molecular dynamics simulations, and the probability of pocket opening is predictive of how potently a compound will inhibit a particular myosin motor.

A novel mathematical modeling framework for antibiotic-resistant bacteria combining within-host microbiome-pathogen interactions with population-level pathogen epidemiology, demonstrating how antibiotic consumption and ecological competition come together to drive the spread of resistance.

A high-throughput analysis of several self-cleaving ribozymes reveals the effect of every possible mutation, and every possible pair of mutations, and how patterns in the relative activity data can be mapped to canonical and non-canonical structural elements.

Reliability and predictability analyses beyond standard measures provide empirically based guidance regarding the design of fear conditioning tasks to assess individual differences and group-level inferences cross-sectionally and longitudinally.

Dimensionality reduction techniques reveal how the organization of neurotransmitter receptor and transporter co-expression in the human brain may bridge the gap between brain structure and function.