2,570 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

    Hessel Honkoop et al.
    Single-cell RNA sequencing reveals Nrg1/ErbB2-induced metabolic reprogramming as a pivotal event for cardiomyocyte proliferation during heart regeneration.
    1. Genetics and Genomics

    Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

    Sebastian I Arriola Apelo et al.
    Metabolic health and longevity can be separated by ovariectomy, which also protects female mice lacking hepatic mTORC2 from midlife mortality.
    1. Cell Biology
    2. Developmental Biology

    Metabolic modulation regulates cardiac wall morphogenesis in zebrafish

    Ryuichi Fukuda et al.
    3D single cell imaging and genetic analyses reveal a new role of cardiac metabolism in cardiac wall morphogenesis.
    1. Computational and Systems Biology

    A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

    Michael A Petr et al.
    A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

    Zaijun Ma et al.
    Epigenetic drift of H3K27me3 is one of the molecular mechanisms that contribute to aging, and stimulation of glycolysis promotes metabolic health and longevity.
    1. Epidemiology and Global Health
    2. Medicine

    Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

    Heli Julkunen et al.
    Metabolic biomarkers measured from single blood test can identify apparently healthy people at high susceptibility for developing severe pneumonia, and may also be useful for preventive COVID-19 screening.
    1. Biochemistry and Chemical Biology

    Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

    Nicole L Jenkins et al.
    As worms age reduced glutathione together with increased ferrous iron increases frailty and leads to ferroptosis, which is amenable to therapeutic intervention.
    1. Cell Biology

    Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis

    Yu A An et al.
    Gain- and loss-of-function studies highlight the important role for angiopoietin-2 to maintain adipose tissue health during metabolic challenges.
    1. Medicine

    Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

    Ying Ann Chiao et al.
    Mitochondrial-targeted SS-31 peptide ameliorates mitochondrial dysfunction and rescues pre-existing cardiac dysfunction in old mice, supporting the translational potential of mitochondrial protective interventions to treat age-related diseases.
    1. Immunology and Inflammation

    Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

    Rabina Mainali et al.
    Integrative multi-omics reveals global dysregulation in hepatic metabolism during prolonged sepsis.

Refine your results by:

Type
Research categories