Browse the search results

Page 2 of 49
    1. Immunology and Inflammation

    Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

    Ankit Jambusaria et al.
    Vascular endothelial cells in the brain, heart and lung exhibit tissue-specific heterogeneity and plasticity, expressing genes that were traditionally thought to be only expressed by the surrounding parenchymal tissue cells.
    1. Developmental Biology

    Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice

    Georges Raad et al.
    Predisposition to obesity-associated diseases is dependent on the ancestors' diet.
    1. Plant Biology

    Building customizable auto-luminescent luciferase-based reporters in plants

    Arjun Khakhar et al.
    A fungal bioluminescence pathway can be reconstituted in planta to create luminescence in many plant species without external substrate addition, and be used to design customizable reporters of gene-expression.
    1. Computational and Systems Biology

    Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments

    Christopher A Jackson et al.
    Single cell expression data can be used to determine how regulatory transcription factors and target genes are connected, and is especially useful when studying transcription factors controlling heterogeneous cell states.
    1. Structural Biology and Molecular Biophysics

    Structural basis for SARM1 inhibition and activation under energetic stress

    Michael Sporny et al.
    Cryo-EM shows that the NADase activity of SARM1 is allosterically inhibited by physiological concentrations of NAD+ that stabilizes an auto-inhibited conformation of SARM1, explaining how NAD+ depletion may inflict neurodegeneration.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells

    Jiajia Xu et al.
    CD107a expression divides osteogenic from adipogenic perivascular precursor cells within human white adipose tissue.
    1. Physics of Living Systems

    A microfluidic device for inferring metabolic landscapes in yeast monolayer colonies

    Zoran S Marinkovic et al.
    Metabolic gradients underlie gene expression patterns within spatially controlled expanding 2D microbial colonies.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community

    Sriram Varahan et al.
    Sufficient aspartate drives specialization within a microbial colony, when some cells use it to create a limited carbon-resource, while other cells consume this resource and use aspartate for nucleotide synthesis.
    1. Cell Biology

    A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC

    Robinson Arce-Molina et al.
    A user-friendly genetically-encoded fluorescent sensor of improved dynamic range is introduced to facilitate the study of mitochondrial metabolism and diversity.
    1. Genetics and Genomics

    Single cell functional genomics reveals the importance of mitochondria in cell-to-cell phenotypic variation

    Riddhiman Dhar et al.
    A genome-wide quantitative microscopy screen implicates mitochondria in single cell variation in proliferation and drug resistance in yeast.