A novel metabolic network analysis method enables large-scale computational predictions of biosynthetic capabilities across the human oral microbiome, revealing a unique cluster of fastidious microorganisms and potential metabolic interdependencies.
Recent functional changes in ancient duplicate genes led to the evolution of divergent regulatory and metabolic strategies by the GALactose gene networks of two yeast species.
Mutations that affect a metabolic network generically exhibit epistasis, which propagates to higher level phenotypes, such as fitness, carrying some information about the network’s topology.
Rat brains mature to increase metabolic connectivity between network components and establish energy efficiency in the midline structures from childhood to early adulthood.
Constraint-based modelling predicts C4 photosynthesis evolves under resource limitation from an ancestral ground state of C3 photosynthesis and attributes divergent metabolic routes in extant C4 subtypes to light.
Computational models and software connect metagenomics to metabolic network reconstruction, assess metabolic complementarity between species, and identify critical species associated to functions of interest.
A near-complete flux balance analysis model of a minimal cell demonstrates the high essentiality of its metabolic genes, agrees well with experimental essentiality data and suggests some further gene removals.
The roundworm C. elegans transcriptionally activates five genes comprising an alternate propionate breakdown pathway when dietary vitamin B12 is low or when the canonical pathway is compromised.
