829 results found
    1. Evolutionary Biology

    Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network

    Meihua Christina Kuang et al.
    Recent functional changes in ancient duplicate genes led to the evolution of divergent regulatory and metabolic strategies by the GALactose gene networks of two yeast species.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans

    Emma Watson et al.
    The roundworm C. elegans transcriptionally activates five genes comprising an alternate propionate breakdown pathway when dietary vitamin B12 is low or when the canonical pathway is compromised.
    1. Computational and Systems Biology

    Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome

    David B Bernstein et al.
    A novel metabolic network analysis method enables large-scale computational predictions of biosynthetic capabilities across the human oral microbiome, revealing a unique cluster of fastidious microorganisms and potential metabolic interdependencies.
    1. Neuroscience

    Maturation of metabolic connectivity of the adolescent rat brain

    Hongyoon Choi et al.
    Rat brains mature to increase metabolic connectivity between network components and establish energy efficiency in the midline structures from childhood to early adulthood.
    1. Plant Biology

    Plant–necrotroph co-transcriptome networks illuminate a metabolic battlefield

    Wei Zhang et al.
    Simultaneously measuring the transcriptomes of both a host plant and fungal pathogen, co-transcriptomics, identified diverse, dynamic and independent communication mechanisms conveying information between the two organisms via discrete gene modules.
    1. Evolutionary Biology

    Metabolism: Evolution retraces its steps to advance

    Daniel J Kliebenstein
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    1. Evolutionary Biology

    Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment

    Erik M Quandt et al.
    A long-term evolution experiment with Escherichia coli shows that the appearance and optimization of a new trait can require both co-opting existing cellular pathways for new roles and reversing a history of previous adaptation.
    1. Ecology
    2. Physics of Living Systems

    Microbial consortia at steady supply

    Thibaud Taillefumier et al.
    In a consumer-resource model obeying the physical requirement of flux conservation, metabolic competition between microbes yields consortia of cell types that collectively resist invasion via optimal use of resources.
    1. Microbiology and Infectious Disease

    Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis

    Aleksandra Agapova et al.
    Metabolomics and stable isotope labelling studies of virulent Mycobacterium tuberculosis reveal a de-centralised metabolic network able to utilise various amino acids as nitrogen sources to a better extent than ammonium.
    1. Biochemistry and Chemical Biology

    Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks

    Suwen Zhao et al.
    Genome neighborhood networks provide an efficient large-scale approach to mine metabolic pathway context for entire families of proteins and enzymes.

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