262 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response

    Xing-Huang Gao et al.
    ATF4, the master regulator of transcription during the Integrated Stress Response (ISR), causes global changes in cysteine sulfhydration of proteins and this event causes cellular metabolic reprogramming.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

    Hessel Honkoop et al.
    Single-cell RNA sequencing reveals Nrg1/ErbB2-induced metabolic reprogramming as a pivotal event for cardiomyocyte proliferation during heart regeneration.
    1. Cell Biology

    HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

    David Wu et al.
    Hemodynamic forces regulate endothelial cell metabolism, which in turn regulates endothelial inflammation.
    1. Developmental Biology

    Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

    Xinde Zheng et al.
    The shutoff of aerobic glycolysis in neuronal differentiation is essential for neuronal survival.
    1. Cell Biology
    2. Plant Biology

    SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants

    Andrea Mair et al.
    The transcription factor bZIP63 is a key regulator of the starvation response in the model plant Arabidopsis thaliana and is directly targeted by the kinase SnRK1.
    1. Neuroscience

    Long-term consequences of the absence of leptin signaling in early life

    Angela M Ramos-Lobo et al.
    A mouse model that grew without functional leptin receptors until adulthood reveals that early defects in leptin signaling lead to permanent metabolic and developmental problems.
    1. Cancer Biology
    2. Cell Biology

    A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a Drosophila tumor model

    Kenneth Kin Lam Wong et al.
    Specific molecular links that orchestrate growth signals and metabolic reprogramming to achieve tumorigenesis are identified as potential metabolic vulnerabilities in cancer treatment.
    1. Structural Biology and Molecular Biophysics

    Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis

    Trayambak Pathak et al.
    Colorectal tumors down-regulate the mitochondrial Na+/Ca2+/Li+ exchanger (NCLX) to alter mitochondrial Ca2+ signaling and initiate transcriptional and metabolic reprogramming that drives tumor chemo-resistance and metastasis.
    1. Immunology and Inflammation

    Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

    Gaojian Lian et al.
    Metabolic reprogramming in suppressing oxidative stress during TH17 cell differentiation.
    1. Cell Biology
    2. Developmental Biology

    In vivo genetic dissection of tumor growth and the Warburg effect

    Cheng-Wei Wang et al.
    A Drosophila tumor model reveals how the activation of an oncogenic pathway can lead to both tumor growth and a reprogramming of metabolism known as the Warberg effect.

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