1,205 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources

    Bram Cerulus et al.
    Live-cell microscopy and genome-wide screens reveal how slow transitions in metabolism can underlie metabolic memory, providing a model for organisms demonstrating similar history-dependent behaviour and routes to improve industrial microbes.
    1. Cell Biology
    2. Developmental Biology

    Mitochondrial fusion is required for spermatogonial differentiation and meiosis

    Grigor Varuzhanyan et al.
    Mitochondrial fusion enables a metabolic transition during spermatogenesis.
    1. Cancer Biology
    2. Genetics and Genomics

    Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

    Jianing Xu et al.
    A distinct class of kidney tumors is characterized not by patterns of somatic mutations, but by a distinct metabolism.
    1. Cell Biology
    2. Computational and Systems Biology

    Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative lifespan

    Simeon Leupold et al.
    With replicative age, S. cerevisiae shifts from a fermentative towards an unusual respiratory metabolism, accompanied by a decrease in growth and glucose uptake rate.
    1. Cell Biology
    2. Immunology and Inflammation

    Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

    Anthony J Covarrubias et al.
    Interleukin 4 signaling co-opts the Akt-mTORC1-Acly pathway to couple metabolic input to the control of energetically demanding processes during macrophage M2 activation.
    1. Developmental Biology

    Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

    Gianpaolo Rando et al.
    Glucocorticoid receptor directly regulates the transcriptional activity of peroxisome proliferator-activated alpha (PPARα) before birth in anticipation of the sudden shifts in the postnatal nutrient source and metabolic demands.
    1. Ecology

    Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis

    John A Burns et al.
    The endosymbiosis between an alga and the spotted salamander shows several parallels to invertebrate-algal symbioses as well as to pathogen associations in vertebrate animals.
    1. Immunology and Inflammation

    Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function

    Marie Bettonville et al.
    Long-term exposure to recipient's alloantigens promotes major metabolic defects in T cells that are independent of PD-1-mediated regulation.
    1. Ecology
    2. Microbiology and Infectious Disease

    Bacterial interspecies interactions modulate pH-mediated antibiotic tolerance

    Andrés Aranda-Díaz et al.
    Shifts in pH that result from metabolic interactions between members of the Drosophila gut microbiota were sufficient to modulate Lactobacillus plantarum tolerance to the antibiotics rifampin and erythromycin.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement

    Aleksandra Zielińska et al.
    Correct cell wall synthesis in bacteria depends on flotillin-mediated membrane fluidity.

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