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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges

    Libin Liu, Paul F Pilch
    PTRF (Cavin-1) mediates metabolism-regulated ribosomal transcription in mature adipocytes, independent of its role in caveolae formation.
    1. Immunology and Inflammation

    Enriched dietary saturated fatty acids induce trained immunity via ceramide production that enhances severity of endotoxemia and clearance of infection

    Amy L Seufert, James W Hickman ... Brooke A Napier
    Enriched dietary SFAs, specifically palmitic acid (PA), induce a broad and long-lived innate immune memory response which is harmful during disease exacerbated by inflammation, but beneficial for pathogen clearance.
    1. Medicine
    2. Computational and Systems Biology

    Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning

    Gitanjali Roy, Rameesha Syed ... Michael A. Kalwat
    Not revised
    Reviewed Preprint v1
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    • Solid
    1. Cell Biology

    Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice

    Chelsea Hepler, Bo Shan ... Rana K Gupta
    Fibro-inflammatory progenitors represent a subpopulation of perivascular cells in visceral adipose tissues of mice that promote inflammation and fibrosis.
    1. Medicine

    Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

    Hong Chen, Lijun Sun ... Yue Yin
    Intermittent fasting affects intestinal immunity through new interactions between macrophages and ILC3s, increasing ILC3 secretion of IL-22 and thus promoting white adipose tissue beigeing, and improving metabolism.
    1. Cell Biology
    2. Medicine

    Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

    Yang Zhang, Gerd Bobe ... Adrian F Gombart
    Identifying xanthohumol and its derivatives as PPARγ anatagonists provides new insight into how natural compounds beneficially treat obesity and metabolic syndrome, and provide new compounds for therapeutic development.
    1. Cell Biology
    2. Medicine

    An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming

    Hong Wang, Xueping Wan ... Libin Liu
    A non-canonical p53 function in adipocyte plays a critical role in energy homeostasis and is involved in obesity-associated metabolic dysfunctions.
    1. Cell Biology
    2. Medicine

    Adipocyte NR1D1 dictates adipose tissue expansion during obesity

    Ann Louise Hunter, Charlotte E Pelekanou ... David A Bechtold
    Clock protein NR1D1 regulates white adipose tissue expansion and development of obesity-related pathology.
    1. Cell Biology
    2. Developmental Biology

    The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

    Ying-Ju Chang, Scott Pownall ... Vuk Stambolic
    PDZ-RhoGEF controls adipose tissue abundance and whole body metabolism.
    1. Computational and Systems Biology
    2. Medicine

    Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

    Hong Yang, Cheng Zhang ... Adil Mardinoglu
    Inhibiting c-Jun N-terminal kinase exerts a cross-tissue therapeutic effect on metabolic dysfunction induced by sucrose overconsumption in rats.
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