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Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice
Shun Kishimoto et al.
Using noise suppression, real-time imaging of glucose metabolism is possible by 13C MRI and reveals previously undetected metabolic differences within tumors.
Immunology and Inflammation
Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function
Marie Bettonville et al.
Long-term exposure to recipient's alloantigens promotes major metabolic defects in T cells that are independent of PD-1-mediated regulation.
is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium
David Wu et al.
Hemodynamic forces regulate endothelial cell metabolism, which in turn regulates endothelial inflammation.
Genetics and Genomics
Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue
Renske Erion et al.
Neuropeptide F/Y from neurons drives rhythmic expression of detoxification-related genes in a peripheral metabolic tissue in flies and mice.
Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer
Keren Yizhak et al.
Genome-scale metabolic modeling of individual cancer cells and healthy human cells identifies specific and selective metabolic vulnerabilities.
Maturation of metabolic connectivity of the adolescent rat brain
Hongyoon Choi et al.
Rat brains mature to increase metabolic connectivity between network components and establish energy efficiency in the midline structures from childhood to early adulthood.
Integration of light and metabolic signals for stem cell activation at the shoot apical meristem
Anne Pfeiffer et al.
TOR kinase guides the transition of plant stem cells from the dormant embryonic state to the active adult state by integrating light and metabolic signals.
Epidemiology and Global Health
Microbiology and Infectious Disease
Paratyphi A elaborate distinct systemic metabolite signatures during enteric fever
Elin Näsström et al.
Metabolite analysis of plasma from enteric fever patients define signals of organism specific host–pathogen interactions and provides opportunities for new diagnostics.
ALKBH7 mediates necrosis via rewiring of glyoxal metabolism
Chaitanya A Kulkarni et al.
Multi-omics reveals that Alkb homolog 7 (ALKBH7), α mitochondrial alpha-ketoglutarate dioxygenase of unclear function, regulates glyoxal metabolism, which may explain its role in necrosis and heart attack.
Physics of Living Systems
Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians
Albert Thommen et al.
A combination of experimental and theoretical analysis identifies body size-dependent energy storage as the physiological cause of 3/4-power law scaling of the metabolic rate in planarians.
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