520 results found
    1. Biochemistry and Chemical Biology

    Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation

    Andrei S Avanesov et al.
    Aging is a process characterized by gradual metabolome remodeling, deceleration of the remodeling in late life and under conditions that extend lifespan, and a mortality-associated pattern of cumulative damage.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Salmonella Typhi and Salmonella Paratyphi A elaborate distinct systemic metabolite signatures during enteric fever

    Elin Näsström et al.
    Metabolite analysis of plasma from enteric fever patients define signals of organism specific host–pathogen interactions and provides opportunities for new diagnostics.
    1. Plant Biology

    An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway

    Frederikke Gro Malinovsky et al.
    Young defense metabolites are often believed to be solely outputs but evidence suggests that they can regulate ancient signaling pathways.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A common bacterial metabolite elicits prion-based bypass of glucose repression

    David M Garcia et al.
    Activity-guided fractionation identifies the first bacterial metabolite that potently induces a prion in nature.
    1. Cell Biology
    2. Computational and Systems Biology

    Self-establishing communities enable cooperative metabolite exchange in a eukaryote

    Kate Campbell et al.
    A eukaryotic cell model overcomes metabolic deficiencies within a complex, self-establishing community that enables the growth-relevant exchange of metabolic intermediates.
    1. Stem Cells and Regenerative Medicine

    Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues

    Andrew W DeVilbiss et al.
    A method was developed for the metabolomic analysis of small numbers of flow cytometrically isolated cells from rare cell populations such as hematopoietic stem cells and circulating cancer cells.
    1. Biochemistry and Chemical Biology

    Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles

    Henry H Le et al.
    Caenorhabditis elegans homologs of carboxylesterases that localize to intestinal organelles orchestrate the assembly of modular signaling molecules from building blocks that integrate diverse metabolic pathways.
    1. Cell Biology
    2. Genetics and Genomics

    Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

    Siming Ma et al.
    Profiling of fibroblasts across mammals captures differences in longevity at the level of global gene expression and metabolite levels and reveals pathways that define these differences.
    1. Cell Biology
    2. Developmental Biology

    Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells

    Zhiwei Lu et al.
    Metabolite mediates communication between stem cells and influences stem cell maintenance.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity

    Sanchari Bhattacharyya et al.
    Weak yet highly species-specific protein-protein interactions enhance the activity of metabolically related enzymes in bacteria at endogenous conditions, but also mean that overexpression of one partner leads to permanent non-physiological complexes and gene dosage toxicity.

Refine your results by:

Type
Research categories