Elucidating the control and regulation of acetate overflow in E. coli reveals that acetate is not only an end-product but also a co-substrate and a global regulator of glucose metabolism.
A neuronal specific function of the mitochondrial chaperone, hTim8a in Complex IV biology provides insight into the pathomechanisms underlying the mitochondrial disease, Mohr-Tranebjaerg syndrome.
A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.
Breast cancer resistant to either doxorubicin or epirubicin relies on distinct primary metabolic processes, which can be targeted to reduce cancer progression.
An integrative study of five biological clocks in somatic and mental health indicate that one's biological age is best reflected by combining aging measures from multiple cellular levels.
Lifelong HAO1 knockout was safe and without clinical phenotype in an identified healthy woman, de-risking a rare disease therapeutic approach through the power of naturally occurring human genetic variation.
Arbuscular mycorrhizal fungi-induced hydroxy- and carboxyblumenol C glycosides accumulate in plant shoots and allow for facile high-throughput screening for functional plant-AMF associations.
Illustrating the impact of host metabolism on infection outcome, loss of the aryl hydrocarbon receptor in radioresistant cells leads to heme-mediated kidney toxicity during malaria.
