86 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples

    Feiqiao Brian Yu et al.
    Microfluidic-based mini-metagenomics enables the investigation of environmental microbial communities in high-throughput and with single-cell resolution, facilitating genome binning and quantification of function, abundance, and genome variation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Metagenomic chromosome conformation capture (meta3C) unveils the diversity of chromosome organization in microorganisms

    Martial Marbouty et al.
    A technique called meta3C provides an elegant and integrated approach to metagenomic analysis by allowing the de novo assembly, scaffolding and 3D characterization of unknown genomes from a complex mix of species
    1. Microbiology and Infectious Disease

    Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

    Kevin J Forsberg et al.
    A high-throughput, activity-based selection identifies many phage-derived inhibitors of Cas9 from human fecal and oral metagenomes, with at least one inhibitor acting via a novel mechanism.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Consistent and correctable bias in metagenomic sequencing experiments

    Michael R McLaren et al.
    A mathematical model of bias in marker-gene and metagenomic sequencing measurements explains systematic errors in defined mixtures of microbial species, and enables quantitative and reproducible investigation of biological communities.
    1. Genetics and Genomics

    Single-amino acid variants reveal evolutionary processes that shape the biogeography of a global SAR11 subclade

    Tom O Delmont et al.
    An in-depth metagenomic analysis of possibly the most abundant and widespread microbial lineage in the surface ocean teases apart evolutionary processes that maintain its genomic heterogeneity and biogeography.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

    Jose U Scher et al.
    The sequencing of microbial genomes reveals that the presence of a particular microbial species in the gut may increase the risk of the autoimmune disease rheumatoid arthritis.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A phylogenetic transform enhances analysis of compositional microbiota data

    Justin D Silverman et al.
    The PhILR transform uses an evolutionary model to overcome statistical challenges associated with microbiota surveys.
    1. Ecology
    2. Genetics and Genomics

    Social networks predict gut microbiome composition in wild baboons

    Jenny Tung et al.
    Social interactions can have a direct effect on the composition of the gut microbiome in wild primates.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Extensive transmission of microbes along the gastrointestinal tract

    Thomas SB Schmidt et al.
    Microbial populations are continuous along the gastrointestinal tract, with increased transmission in colorectal cancer and rheumatoid arthritis patients.

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