Structural, biochemical, and proteomic analyses of a four-subunit core module of the cleavage and polyadenylation specificity factor complex reveal its molecular architecture and specific determinants of polyadenylation signal recognition in human mRNAs.

MBLAC1 is an endoribonuclease specific for replication dependent histone pre-mRNA processing during S-phase and may represent a new type of cancer target.

Comprehensive mutational characterisation of VIM-2 metallo-beta-lactamase deciphered the residues responsible for key functional behavior, including translocation, stability, substrate recognition and catalysis.

One-step Isolation and Lysis (OIL) PCR offers a robust, versatile, accessible, and high-throughput method for linking mobile DNA with bacterial hosts in natural microbial communities.

Prodrug antibiotics can be designed that are serum-stable but readily cleaved inside bacterial pathogens.

Genetic, phenotypic, and evolutionary analysis of a clinical isolate provides an explanation of the intricate genetic factors behind non-carbapenemase carbapenem resistance and sheds light on the evolutionary mechanisms that influence the molecular basis of antibiotic resistance.