89 results found
    1. Neuroscience

    Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis

    Sayali V Gore et al.
    Chronic dysregulation of matrix-metalloproteinase 9, which is associated with some neurodevelopmental disorders, leads to local hyperconnectivity in the developing brain, resulting in altered sensory processing and increased seizure susceptibility.
    1. Cell Biology
    2. Developmental Biology

    Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles

    Julia Sauerwald et al.
    Tracheal-derived matrix metalloproteinase 1 activity sustains tracheal branch invasion into myotubes by modulating ECM properties and dynamic behavior of sprouting tip cells.
    1. Developmental Biology

    Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster

    Yuto Yoshinari et al.
    Genetic analyses using the fruit fly illustrate how neuronal system couples germline stem cell increase to an external cue, which is mating, through stem cell niche signaling.
    1. Developmental Biology

    The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition

    Chengdong Liu et al.
    Zinc metalloproteinase Papp-aa-mediated Igfbp5 proteolysis functions as a [Ca2+]-regulated molecular switch linking IGF signaling to epithelial cell proliferation and bone calcification.
    1. Cell Biology
    2. Developmental Biology

    Matrix metalloproteinase 14 is required for fibrous tissue expansion

    Susan H Taylor et al.
    The membrane type I-matrix metalloproteinase is essential for the release of collagen fibrils from plasma membrane fibripositors, which is required for the transition from embryonic to postnatal tendon development.
    1. Neuroscience

    A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade

    Maria D Purice et al.
    An unbiased transcriptional profiling screen reveals the secreted matrix metalloproteinase MMP-1 is a transcriptional target of the ensheathing glial receptor Draper following acute axon injury in adult Drosophila.
    1. Neuroscience

    Homeostatic regulation of perisynaptic matrix metalloproteinase 9 (MMP9) activity in the amblyopic visual cortex

    Sachiko Murase et al.
    Dark exposure lowers the MMP9 activation threshold, and subsequent light stimulation to an amblyopic eye is sufficient to induce proteolysis at thalamo-cortical synapses in deprived mouse visual cortex.
    1. Cell Biology
    2. Neuroscience

    Site-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs

    Zora Chui-Kuen Chan et al.
    Postsynaptic MT1-MMP serves as a molecular switch to synaptogenesis by clearing the surrounding ECM environment that allows effective deposition of nerve-derived synaptogenic factors to induce postsynaptic differentiation at developing NMJs.
    1. Medicine

    7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

    Fan Xue et al.
    In vitro and in vivo studies highlight the dual regulatory effects that 7,8-dihydroxyflavone exerts on bone formation and resorption.
    1. Structural Biology and Molecular Biophysics

    A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

    Andrea Saponaro et al.
    Cell-penetrating peptide drugs prevent adrenergic regulation of pacemaker channels without altering the overall response of the cell to cAMP.

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