Experimental efforts to validate the output of a computational model that predicts new uses for existing drugs highlights the inherently complex nature of cancer biology.

Biological variability has confounded efforts to confirm the role of PREX2 mutations in melanoma.

The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.

Scientific abstracts have become less readable over the past 130 years, in part because recent texts include more general scientific jargon than older texts.

The association between the bacterium Fusobacterium nucleatum and human colon cancer is more complicated than it first appeared.

Targeting the transcription factor c-Myc via one of its coactivator proteins is a promising strategy for cancer therapy.

The first results from the Reproducibility Project: Cancer Biology suggest that there is scope for improving reproducibility in pre-clinical cancer research.

Editors' Summary: This Replication Study has reproduced important parts of the original paper.

Editors' Summary: This Replication Study has reproduced important parts of the original paper.