33 results found
    1. Cancer Biology

    Reproducibility in Cancer Biology: The challenges of replication

    Interpreting the first results from the Reproducibility Project: Cancer Biology requires a highly nuanced approach.
    Editorial
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    1. Cancer Biology

    Reproducibility in Cancer Biology: Rethinking research into metastasis

    Peter Friedl
    The partial success of an attempt to repeat findings in cancer biology highlights the need to improve study designs for preclinical research into metastasis and the targeting of cancer cells.
    Insight
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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Reproducibility in Cancer Biology: Getting to grips with c-Myc

    Dirk Eick
    The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.
    Insight
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    1. Cancer Biology

    Reproducibility in Cancer Biology: Mixed outcomes for computational predictions

    Chi Van Dang
    Experimental efforts to validate the output of a computational model that predicts new uses for existing drugs highlights the inherently complex nature of cancer biology.
    Insight
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    1. Cancer Biology

    Reproducibility in Cancer Biology: Melanoma mystery

    Roger J Davis
    Biological variability has confounded efforts to confirm the role of PREX2 mutations in melanoma.
    Insight
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    1. Cancer Biology

    Reproducibility in Cancer Biology: Pseudogenes, RNAs and new reproducibility norms

    George A Calin
    The partial success of a study to reproduce experiments that linked pseudogenes and cancer proves that understanding RNA networks is more complicated than expected.
    Insight
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  1. Research: The readability of scientific texts is decreasing over time

    Pontus Plavén-Sigray et al.
    Scientific abstracts have become less readable over the past 130 years, in part because recent texts include more general scientific jargon than older texts.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Science Forum: The Brazilian Reproducibility Initiative

    Olavo B Amaral et al.
    Researchers are undertaking a systematic assessment of the reproducibility of biomedical science in Brazil.
    1. Cancer Biology

    Reproducibility in Cancer Biology: Making sense of replications

    Brian A Nosek, Timothy M Errington
    The first results from the Reproducibility Project: Cancer Biology suggest that there is scope for improving reproducibility in pre-clinical cancer research.
    1. Cancer Biology

    Reproducibility in Cancer Biology: Small molecules remain on target for c-Myc

    Linchong Sun, Ping Gao
    Targeting the transcription factor c-Myc via one of its coactivator proteins is a promising strategy for cancer therapy.
    Insight
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