46 results found
    1. Epidemiology and Global Health

    Region of Attainable Redaction, an extension of Ellipse of Insignificance analysis for gauging impacts of data redaction in dichotomous outcome trials

    David Robert Grimes
    Region of Attainable Redaction analysis allows scientists to estimate the potential impacts of redaction in biomedical science, helping to uncover potentially spurious or non-robust results.
    1. Neuroscience

    Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility

    Reto B Cola, Diana M Roccaro-Waldmeyer ... Marco R Celio
    Foxb1-expressing hypothalamic neurons in the parvafox nucleus and the dorsal premammillary nucleus both contribute to behavioral and physiological components associated with defensive behavior.
    1. Computational and Systems Biology

    Analysis of NIH K99/R00 awards and the career progression of awardees

    Nicole C Woitowich, Sarah R Hengel ... Daniel J Tyrrell
    There is a significant disadvantage to receive a major grant (i.e., R01) for K99/R00 awardees that are women, those at lower funded institutions, and those with lower career mobility.
    1. Neuroscience

    ChatGPT identifies gender disparities in scientific peer review

    Jeroen PH Verharen
    Generative artificial intelligence, such as OpenAI’s ChatGPT, can be used to analyze scientific texts with specialized constructions, including peer review reports.
    1. Neuroscience

    Science Forum: How failure to falsify in high-volume science contributes to the replication crisis

    Sarah M Rajtmajer, Timothy M Errington, Frank G Hillary
    An increased emphasis on falsification – the direct testing of strong hypotheses – will lead to faster progress in science by allowing well-specified hypotheses to be eliminated.
  1. Meta-Research: Investigating disagreement in the scientific literature

    Wout S Lamers, Kevin Boyack ... Dakota Murray
    An approach based on cue phrases can be used to identify instances of disagreement in scientific articles and compare the level of disagreement in various disciplines.
    1. Cancer Biology

    Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology

    Timothy M Errington, Alexandria Denis ... Brian A Nosek
    A project to repeat experiments from high-impact papers in cancer biology encountered a series of challenges, many of which were caused by a lack of detail in the original papers.
    1. Medicine
    2. Neuroscience

    Science Forum: Consensus-based guidance for conducting and reporting multi-analyst studies

    Balazs Aczel, Barnabas Szaszi ... Eric-Jan Wagenmakers
    Using multiple analysts to independently analyze the same dataset has the potential to explore and strengthen the robustness of results and conclusions in basic and applied research.
  2. Webinar Report: The "science of science" - using meta-research to make research more transparent and reproducible

    Watch back as our panelists explore ways that you can use meta-research, or the science of science, to make research more transparent, rigorous and reproducible.

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