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The partial success of an attempt to repeat findings in cancer biology highlights the need to improve study designs for preclinical research into metastasis and the targeting of cancer cells.

Researchers are undertaking a systematic assessment of the reproducibility of biomedical science in Brazil.

Biological variability has confounded efforts to confirm the role of PREX2 mutations in melanoma.

Experimental efforts to validate the output of a computational model that predicts new uses for existing drugs highlights the inherently complex nature of cancer biology.

Targeting the transcription factor c-Myc via one of its coactivator proteins is a promising strategy for cancer therapy.

The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.

Scientific abstracts have become less readable over the past 130 years, in part because recent texts include more general scientific jargon than older texts.

The first results from the Reproducibility Project: Cancer Biology suggest that there is scope for improving reproducibility in pre-clinical cancer research.