67 results found
    1. Structural Biology and Molecular Biophysics

    Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

    Gregory M Martin et al.
    Diverse KATP channel inhibitors occupy a common binding pocket and stabilize an interaction between Kir6.2 and SUR1 to allosterically control gating and promote the assembly and trafficking of nascent channels.
    1. Structural Biology and Molecular Biophysics

    Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

    Zhicheng Zuo et al.
    The catalytic activation of the Cas9 HNH domain involves a unique conformational change in the ββα-metal motif that is collectively driven by the interactions with the metal ions and DNA.
    1. Structural Biology and Molecular Biophysics

    Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis

    Chantal L Márquez et al.
    Disassembly of the HIV-1 capsid is a catastrophic process, whereby initiation and propagation can be controlled independently by molecules that bind to different features of the capsid lattice.
    1. Structural Biology and Molecular Biophysics

    Pore mutation N617D in the skeletal muscle DHPR blocks Ca2+ influx due to atypical high-affinity Ca2+ binding

    Anamika Dayal et al.
    Characterization of Ca2+ selectivity and non-conductance mechanism induced by pore mutation N617D in the skeletal muscle DHPR.
    1. Evolutionary Biology

    Group phenotypic composition in cancer

    Jean-Pascal Capp et al.
    Tumoral group phenotypic compositions and their relationships with the fitness of individual malignant cells in different ecological contexts represent crucial, previously unexplored dynamics in tumor progression.
    1. Structural Biology and Molecular Biophysics

    Structural basis for the reaction cycle of DASS dicarboxylate transporters

    David B Sauer et al.
    Structures of multiple states of two dicarboxylate transporters explain the conformational changes needed for substrate import.
    1. Biochemistry and Chemical Biology

    Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering

    Hongki Song et al.
    Sec18(NSF) and Sec17(αSNAP) provide a parallel pathway to fusion that is independent of energy from SNARE zippering.
    1. Structural Biology and Molecular Biophysics

    Identification of ligand-specific G protein-coupled receptor states and prediction of downstream efficacy via data-driven modeling

    Oliver Fleetwood et al.
    Ligands with different efficacy profiles shift the free energy landscape of the beta2 adrenergic receptor activation and stabilize diverse active-like states via the switch of microswitches lining an allosteric pathway.
    1. Neuroscience
    2. Physics of Living Systems

    The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores

    Zhenyong Wu et al.
    During neurotransmitter release, calcium-induced membrane insertion of the C2B domain of Synaptotagmin re-orients the bound SNARE complex which dilates the fusion pore in a mechanical lever action.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics

    Stanley Nithianantham et al.
    Soluble αβ-tubulin assembly is regulated by a cage-like molecular complex containing tubulin cofactors and Arl2.

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