390 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Hedgehog signaling is required for endomesodermal patterning and germ cell development in the sea anemone Nematostella vectensis

    Cheng-Yi Chen et al.
    The dependence of Nematostella germ cell specification on zygotic Hedgehog pathway activity supports the hypothesis that the eumetazoan common ancestor segregated its germline by inductive signals rather than maternal determinants.
    1. Cancer Biology
    2. Cell Biology

    Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling

    Yingqi Liu et al.
    PRMT7-mediated SHANK2 methylation regulates breast cancer metastasis by activating endosomal FAK signals, and may provide potential clues for tumour metastasis treatment strategies.
    1. Cancer Biology
    2. Human Biology and Medicine

    The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model

    Jaime N Wertman et al.
    L-mimosine and dopamine protect against cisplatin-induced oto- and nephrotoxicity in zebrafish and human cell line models.
    1. Cancer Biology
    2. Genetics and Genomics

    Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer

    Syn Kok Yeo et al.
    The unraveling of distinct mammary tumor hierarchies in various mouse models of breast cancer emphasizes the need to account for specific cell states with potentially varying therapeutic vulnerabilities in tumors.
    1. Computational and Systems Biology
    2. Developmental Biology

    Universality of clonal dynamics poses fundamental limits to identify stem cell self-renewal strategies

    Cristina Parigini, Philip Greulich
    Stem cell self-renewal strategies fall into two classes, and only strategies of different classes can be experimentally distinguished via static clonal data.
    1. Cancer Biology

    NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

    Joana G Marques et al.
    In fusion-positive rhabdomyosarcoma, CHD4 positively regulates super-enhancer-mediated gene expression by allowing a chromatin architecture at these cis-regulatory regions, which is permissive to the binding of the transcription factor PAX3-FOXO1.
    1. Structural Biology and Molecular Biophysics

    Structural basis of mitochondrial translation

    Shintaro Aibara et al.
    Structural analysis of translating human mitoribosome illustrates elemental steps of translation in mitochondria.
    1. Developmental Biology

    TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex

    Dario Zimmerli et al.
    The developmental transcription factor TBX3 co-operates with β-catenin co-factors to operate tissue-specific transcriptional outputs, during forelimb development and colorectal cancer progression.

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