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DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs
Samantha VH Bayer et al.
The action of the collagen receptor DDR2 in CAFs regulates Rap1-Talin1 mediated Integrin mechanotransduction in breast tumors to impact tumor stiffness and metastases.
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation
Pirita Pekkonen et al.
The melanoma cell interaction with lymphatic endothelial cells promotes melanoma metastasis by inducing a reversible switch to invasively sprouting melanoma cells.
Human Biology and Medicine
Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters
Alexandra Naba et al.
Many extracellular matrix proteins that are up-regulated during breast tumor progression enhance metastasis, and some are prognostic indicators of poor survival.
Registered report: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis
Steven Fiering et al.
Reproducibility in Cancer Biology: Rethinking research into metastasis
The partial success of an attempt to repeat findings in cancer biology highlights the need to improve study designs for preclinical research into metastasis and the targeting of cancer cells.
Registered report: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Jake Lesnik et al.
Registered report: Interactions between cancer stem cells and their niche govern metastatic colonization
Francesca Incardona et al.
Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
Xuefei Yan et al.
Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
Jia Li et al.
Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis
Marie-Julie Nokin et al.
Carbonyl stress mediated by Methylglyoxal affects Hsp90 activity, inhibits the Hippo pathway and promotes tumor growth and metastasis in breast cancer.
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