18 results found
    1. Human Biology and Medicine

    Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

    William W Wheaton et al.
    The anti-diabetic drug metformin, currently in clinical trials as a potential anti-cancer agent, reduces tumor growth by inhibiting mitochondrial complex I of human cancer cells.
    1. Cell Biology

    Metformin extends C. elegans lifespan through lysosomal pathway

    Jie Chen et al.
    Metformin extends C. elegans lifespan through lysosome-dependent coordination of TORC1 and AMPK pathways.
    1. Neuroscience

    Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease

    Isabelle Arnoux et al.
    In a premanifest mouse model of Huntington's disease at a stage very far from disease onset, significant network and behavior dysregulation was found, being rebalanced by treatment with metformin.
    1. Cancer Biology
    2. Cell Biology

    AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin

    Nicolas Aznar et al.
    An effector of AMPK is essential for the kinase and its pharmacological activators, including Metformin, to strengthen cell-cell junctions and preserve epithelial cell polarity and barrier functions in the face of energetic stress, as well as to suppress oncogenesis.
    1. Human Biology and Medicine

    ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

    Wieneke Dijk et al.
    During sustained cold exposure, lipid fuel is specifically directed towards brown adipose tissue, but not white adipose tissue, via cold-induced regulation of Angiopoietin-like 4 (ANGPTL4).
    1. Computational and Systems Biology
    2. Human Biology and Medicine

    Mitochondrial DNA copy number variation across human cancers

    Ed Reznik et al.
    Many tumors are depleted of mitochondrial DNA; this depletion is associated with changes in gene expression and with the incidence of critical somatic mutations and alterations.
    1. Cancer Biology
    2. Cell Biology

    Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

    Marie-Julie Nokin et al.
    Carbonyl stress mediated by Methylglyoxal affects Hsp90 activity, inhibits the Hippo pathway and promotes tumor growth and metastasis in breast cancer.
    1. Cell Biology
    2. Developmental Biology

    Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

    Barak Blum et al.
    Loss of mature β cell identity in diabetes can be prevented and rescued by small molecule inhibitors of the TGFβ pathway.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Reduced expression of C/EBPβ-LIP extends health and lifespan in mice

    Christine Müller et al.
    Reduced expression of a single transcription factor is sufficient to improve fitness and health at old age and increases the lifespan in female mice.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells

    Yin P Hung et al.
    Individual cells display heterogeneous fluctuations in metabolic activity, with amplitude and kinetics controlled by interlocking feedbacks between glycolysis and the Insulin/PI3K/Akt signaling pathway.

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