59 results found
    1. Cell Biology

    Protective mitochondrial fission induced by stress-responsive protein GJA1-20k

    Daisuke Shimura et al.
    Stress-induced alternative translation of an otherwise common gap junction protein generates an isoform that orchestrates protective mitochondrial fission and organ protection during anticipated ischemia.
    1. Microbiology and Infectious Disease

    Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression

    Isao Masuda et al.
    Biochemical and genome-wide analysis demonstrates that m1G37 is important for tRNA aminoacylation and for the entire elongation cycle of protein synthesis.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A covariation analysis reveals elements of selectivity in quorum sensing systems

    Samantha Wellington Miranda et al.
    The extension of covariation analyses to proteins that coevolve but do not physically interact enabled identification of selectivity residues in quorum sensing proteins, providing insight into the evolution of signaling systems.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide

    Robert P Fuchs et al.
    DNA lesions formed by alkylating agents trigger double-strand breaks, in the absence of replication, by the action of MMR and BER at nearby O-alkyl and N-alkyl adducts, respectively.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A fusion peptide in preS1 and the human protein disulfide isomerase ERp57 are involved in hepatitis B virus membrane fusion process

    Jimena Pérez-Vargas et al.
    The mechanism triggering HBV membrane fusion involves ERp57, a cellular protein disulfide isomerase, and ultimately leads to the exposition of a fusion peptide that was identified in the pre-S1 determinant.
    1. Biochemistry and Chemical Biology

    Post-translational flavinylation is associated with diverse extracytosolic redox functionalities throughout bacterial life

    Raphaël Méheust et al.
    Bioinformatic and biochemical studies provide evidence that covalently bound flavins are common and participate in wide-ranging extracytosolic redox activities throughout bacterial life.
    1. Computational and Systems Biology

    A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

    Michael A Petr et al.
    A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.
    1. Biochemistry and Chemical Biology

    Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

    Vidyasiri Vemulapalli et al.
    Monitoring SHP2 phosphoproteome dynamics identifies new substrate sites and sites protected from dephosphorylation by its SH2 domains, highlighting distinct scaffolding and catalytic activities in effecting a transmembrane signaling response.
    1. Cell Biology

    A nuclear-based quality control pathway for non-imported mitochondrial proteins

    Viplendra PS Shakya et al.
    During times of mitochondrial impairment, non-imported mitochondrial precursor proteins are targeted to the nucleus for proteasome-dependent degradation.
    1. Cell Biology
    2. Developmental Biology

    TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

    Xiaochen Fan et al.
    Network propagation connects TWIST1 with epigenetic regulators CHD7, CHD8, and WHSC1, which collectively promote the bias toward neural crest while suppressing neural stem cell programmes, and subsequently enhance ectomesenchyme potential.

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