59 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion

    Viktoria Désirée Paul et al.
    Two newly identified assembly factors for the ribosome-associated iron-sulfur protein Rli1 reveal a general mechanism for how the cytosolic iron-sulfur protein assembly (CIA) machinery recruits apoproteins.
    1. Cell Biology

    A nuclear-based quality control pathway for non-imported mitochondrial proteins

    Viplendra PS Shakya et al.
    During times of mitochondrial impairment, non-imported mitochondrial precursor proteins are targeted to the nucleus for proteasome-dependent degradation.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A unifying mechanism for the biogenesis of membrane proteins co-operatively integrated by the Sec and Tat pathways

    Fiona J Tooke et al.
    Bioinformatics and experimental approaches identify families of membrane proteins requiring the co-ordinated action of the Sec pathway and Tat pathways for their integration and define features of the polypeptides that mediate interaction with these pathways.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response

    Xing-Huang Gao et al.
    ATF4, the master regulator of transcription during the Integrated Stress Response (ISR), causes global changes in cysteine sulfhydration of proteins and this event causes cellular metabolic reprogramming.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Structured illumination with particle averaging reveals novel roles for yeast centrosome components during duplication

    Shannon Burns et al.
    Visualization of yeast spindle pole proteins using a new microscopy method shows that assembly into the nuclear membrane occurs at the same time as duplication.
    1. Computational and Systems Biology

    A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

    Michael A Petr et al.
    A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.
    1. Biochemistry and Chemical Biology

    Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation

    Andrei S Avanesov et al.
    Aging is a process characterized by gradual metabolome remodeling, deceleration of the remodeling in late life and under conditions that extend lifespan, and a mortality-associated pattern of cumulative damage.
    1. Microbiology and Infectious Disease

    Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression

    Isao Masuda et al.
    Biochemical and genome-wide analysis demonstrates that m1G37 is important for tRNA aminoacylation and for the entire elongation cycle of protein synthesis.
    1. Structural Biology and Molecular Biophysics

    A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore

    Priscilla S-W Yeung et al.
    Electrophysiological and molecular modeling studies identify a sulfur-aromatic interaction between the hydrophobic channel gate and a nearby methionine residue, termed the "gate latch", which is essential for Orai1 pore opening.
    1. Cancer Biology
    2. Cell Biology

    PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

    Chiho Kim et al.
    Identification of PARP1 trapping as the major contributor of PARP1 inhibitor-induced innate immune response.

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