58 results found
    1. Structural Biology and Molecular Biophysics

    Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of ‘quasi-ordered’ states

    Amanda F Clouser et al.
    Multiple iso-energetic-specific interactions involving the intrinsically-disordered region of sHSP HSPB1 define a quasi-ordered state, providing insights into inherited disease-associated mutations within the region that are thought to be disordered.
    1. Structural Biology and Molecular Biophysics

    Structural mapping of oligomeric intermediates in an amyloid assembly pathway

    Theodoros K Karamanos et al.
    Solution NMR provides structural and kinetic information about oligomers on pathway to amyloid fibrils that are precisely structured but not cytotoxic.
    1. Developmental Biology

    Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6

    Yi Xin et al.
    Genetics, in vivo imaging, and unbiased chemical biology screens reveal that Trpv6 functions as a cellular quiescence regulator and delineates a Trpv6-mediated Ca2+ signaling pathway maintaining the quiescent state.
    1. Epidemiology and Global Health

    Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health

    Neil Martin Davies et al.
    Many of the effects of intelligence on health and social outcomes later in life are mediated via education.
    1. Structural Biology and Molecular Biophysics

    Mechanism of completion of peptidyltransferase centre assembly in eukaryotes

    Vasileios Kargas et al.
    Cryo-EM reveals how the central functional site of the ribosome is assembled and provides a framework to interpret the consequences of mutations linked to leukaemia-associated ribosomopathies.
    1. Structural Biology and Molecular Biophysics

    An order-to-disorder structural switch activates the FoxM1 transcription factor

    Aimee H Marceau et al.
    Structural and biochemical analysis reveals that two intrinsically disordered domains of the transcription factor FoxM1 co-fold to form an autoinhibited conformation, which is disrupted by a specific activating phosphorylation event.
    1. Developmental Biology

    The Hox transcription factor Ubx stabilizes lineage commitment by suppressing cellular plasticity in Drosophila

    Katrin Domsch et al.
    The Hox transcription factor Ultrabithorax (Ubx) represses alternative gene programs during lineage development by lineage-specific Polycomb protein complex retention at Ubx-targeted chromatin sites.
    1. Cell Biology
    2. Neuroscience

    Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability

    Shirley Weiss et al.
    An unbiased genetic screen in Drosophila provides evidence for a direct link between glial Ca2+ 25 signaling and classical functions of glia in buffering external K+ as a mechanism to regulate neuronal excitability.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Membrane bridging by Munc13-1 is crucial for neurotransmitter release

    Bradley Quade et al.
    Cryo-electron tomography, reconstitution, and electrophysiological data show that a fundamental function of Munc13-1 is to bridge synaptic vesicles to the presynaptic plasma membrane.
    1. Neuroscience

    Potentiation of cerebellar Purkinje cells facilitates whisker reflex adaptation through increased simple spike activity

    Vincenzo Romano et al.
    Physiological and behavioral analyses show that expression of cerebellar whisker learning can be mediated by increased simple spike activity, depending on LTP induction at parallel fiber to Purkinje cell synapses.

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