59 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila

    Wael Bazzi et al.
    Distinct hematopoietic waves interact via transcriptional cascades specific to embryonic hemocytes to ensure the proper immune response in Drosophila.​.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate

    Diana C Rodriguez Camargo et al.
    The ability of lipid nanodiscs to trap different types of amyloid intermediates, as successfully demonstrated in this study for human-IAPP, could become one of the most powerful approaches to dissect the complicated misfolding pathways of protein aggregation.
    1. Cell Biology
    2. Neuroscience

    The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling

    Kathryn P Harris et al.
    Syntaxin 4 regulates retrograde signaling in the postsynaptic compartment at Drosophila synapses by controlling trafficking of Neuroligin and Synaptotagmin 4 cargo.
    1. Developmental Biology
    2. Neuroscience

    Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

    Timothy A Evans et al.
    The Roundabout2 receptor acts non-autonomously to promote commissural axons to cross the midline by antagonizing Slit-dependent axon repulsion.
    1. Epidemiology and Global Health

    Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health

    Neil Martin Davies et al.
    Many of the effects of intelligence on health and social outcomes later in life are mediated via education.
    1. Neuroscience

    Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle release and replenishment in a dosage-dependent manner

    Zhuo Guan et al.
    Drosophila synaptotagmin 7 functions to restrict SV availability and release, but does not act as the Ca2+ sensor mediating the asynchronous release and facilitation remaining in synaptotagmin 1 mutants.
    1. Chromosomes and Gene Expression

    Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan

    Zheng Hu et al.
    Activation of the stress response pathway in young cells extends replicative lifespan, not by reducing global protein synthesis per se, but by Gcn4-mediated autophagy induction.
    1. Neuroscience

    Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses

    Yulia Akbergenova et al.
    Active zone release probability is correlated with calcium channel density and calcium influx at single release sites, with release strength increasing in an activity-dependent manner during synapse maturation.
    1. Cell Biology
    2. Neuroscience

    Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability

    Shirley Weiss et al.
    An unbiased genetic screen in Drosophila provides evidence for a direct link between glial Ca2+ 25 signaling and classical functions of glia in buffering external K+ as a mechanism to regulate neuronal excitability.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda

    François Blanquart et al.
    Analysis of epidemiological data reveals that viral loads in newly HIV-1 infected individuals in Uganda have declined for two decades, and evolutionary modelling shows that attenuation of the virus explains this decline.

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