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    1. Structural Biology and Molecular Biophysics

    Structural mapping of oligomeric intermediates in an amyloid assembly pathway

    Theodoros K Karamanos et al.
    Solution NMR provides structural and kinetic information about oligomers on pathway to amyloid fibrils that are precisely structured but not cytotoxic.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion

    Ewa Sitarska et al.
    Biophysical and functional data strongly support the notion that Munc18-1 acts as a template to assemble the neuronal SNARE complex, and that inhibition of this activity underlies diverse forms of regulation of neurotransmitter release.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis

    Ponni Rajagopal et al.
    Small decreases in pH associated with cellular stress conditions unleash a cryptic mode of client binding in a ubiquitously expressed human small heat shock protein that is more effective at delaying client aggregation.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Membrane bridging by Munc13-1 is crucial for neurotransmitter release

    Bradley Quade et al.
    Cryo-electron tomography, reconstitution, and electrophysiological data show that a fundamental function of Munc13-1 is to bridge synaptic vesicles to the presynaptic plasma membrane.
    1. Cell Biology
    2. Developmental Biology

    Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina

    Harri Elamaa et al.
    Identification of importance of Angiopoietin-4 (Angpt4) as a first growth factor that initiates venous specification in the peripheral retina, and Angpt4-dependent mechanism for fluid clearance in the mouse retina.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1

    Joseph S Harrison et al.
    Epigenetic modifications to DNA can regulate E3 ubiquitin ligase activity in human cells.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Bile salt receptor complex activates a pathogenic type III secretion system

    Peng Li et al.
    Microbial genetics and biophysical analyses provide insight into an evolutionarily conserved bile salt receptor complex used by pathogenic bacteria to sense their environment.
    1. Computational and Systems Biology
    2. Neuroscience

    Mapping nonlinear receptive field structure in primate retina at single cone resolution

    Jeremy Freeman et al.
    Multi-electrode recordings and modeling are combined to reveal the transformations of signals from cones to bipolar cells and then to ganglion cells within the primate retina.
    1. Structural Biology and Molecular Biophysics

    Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation

    Lukasz Wieteska et al.
    The molecular chaperone BIP from the endoplasmic reticulum is fine-tuned postranslationally through the thermodynamic and kinetic alterations in its conformational ensemble of functionally and structurally distinct physiological forms.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome

    Emma A Morrison et al.
    The BPTF PHD finger is inhibited from binding the methylated H3 tails in the context of the nucleosome due to their robust interaction with the nucleosomal DNA, which can be modulated by additional histone PTMs.