Browse the search results

Page 2 of 380
    1. Cancer Biology
    2. Immunology and Inflammation

    SLAMF6​ deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint

    Emma Hajaj et al.
    SLAMF6 is an inhibitory checkpoint of T cells, the lack of which leads to better tumor control, suggesting a new immunotherapy target.
    1. Cell Biology
    2. Developmental Biology

    Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion

    Yfat Yahalom-Ronen et al.
    Compliant matrix provides a permissive micoenvironment for cardiomyocyte dedifferentiation, cell division and expansion, and thus may open a new avenue towards cardiac regeneration.
    1. Computational and Systems Biology

    In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

    Maria Pernemalm et al.
    Comprehensive mass spectrometry analysis of human plasma proteome reveals tissue leakage proteins, describes variability between individual plasma proteomes and demonstrates protein transfer across the placenta during pregnancy.
    1. Neuroscience

    Human hippocampal CA3 damage disrupts both recent and remote episodic memories

    Thomas D Miller et al.
    Human hippocampal cornu ammonis 3 damage impairs both recent and remote autobiographical episodic memory, and disrupts functional integration in medial temporal lobe subsystem regions of the default network.
    1. Computational and Systems Biology

    The structural connectome constrains fast brain dynamics

    Pierpaolo Sorrentino et al.
    The fast spreading of neural activity across the brain has a complex structure, imposed by the white-matter bundles.
    1. Epidemiology and Global Health

    Mapping imported malaria in Bangladesh using parasite genetic and human mobility data

    Hsiao-Han Chang et al.
    Human mobility drives malaria importation within countries and threatens elimination interventions, but can be measured using new approaches that combine parasite genetics, mobile phone data, travel surveys and models.
    1. Medicine

    Point of View: Why clinical translation cannot succeed without failure

    Alex John London, Jonathan Kimmelman
    The high rates of attrition that occur in drug development are widely regarded as problematic, but the failure of well-designed studies benefits both researchers and healthcare systems.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Improving oligo-conjugated antibody signal in multimodal single-cell analysis

    Terkild B Buus et al.
    Oligo-conjugated antibodies are a powerful tool but require thorough optimization to reduce background signal, increase sensitivity, and reduce sequencing costs.
    1. Neuroscience

    The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan

    Anders Martin Fjell et al.
    Volumetric lifespan change in subcortical structures follows fundamental principles of brain development, lifespan continuity, genetic organization, and age-invariant relationships to cognition.
    1. Medicine
    2. Epidemiology and Global Health

    Mapping residual transmission for malaria elimination

    Robert C Reiner Jr et al.
    A fine-grain map of residual transmission and importation in Swaziland shows where to target malaria elimination efforts.