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    1. Cell Biology
    2. Developmental Biology

    Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells

    Melissa T Adams, JaeAnn M Dwulet ... Barak Blum
    Synchronized β cell response to glucose is lost concomitant with loss of islet architecture in Robo-deficient islets of Langerhans in vivo.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stem Cells: Investigating the impact of cannabis

    Merrick Pierson Smela
    The psychoactive component of cannabis, ∆9-THC, affects cell growth and metabolism in early embryonic cell types in mice.
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    1. Genetics and Genomics

    A genetic and linguistic analysis of the admixture histories of the islands of Cabo Verde

    Romain Laurent, Zachary A Szpiech ... Paul Verdu
    The complex histories of social relationships between enslaved and non-enslaved communities and their descendants during and after the Trans-Atlantic Slave-Trade shaped the detailed genetic and linguistic histories of admixture of the islands of Cabo Verde.
    1. Neuroscience

    Body size as a metric for the affordable world

    Xinran Feng, Shan Xu ... Jia Liu
    The human body shapes how we perceive and interact with the environment, with body size serving as a boundary for defining potential actions, hereby enlightening research on foundation agents.
    1. Cell Biology
    2. Neuroscience

    The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

    Heather S Comstra, Jacob McArthy ... Victor Faundez
    The ATP7A interactome is the first comprehensive view of putative Menkes disease neurodegeneration mechanisms.
    1. Cancer Biology
    2. Immunology and Inflammation

    SLAMF6​ deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint

    Emma Hajaj, Galit Eisenberg ... Michal Lotem
    SLAMF6 is an inhibitory checkpoint of T cells, the lack of which leads to better tumor control, suggesting a new immunotherapy target.
    1. Neuroscience

    Neurophysiological trajectories in Alzheimer’s disease progression

    Kiwamu Kudo, Kamalini G Ranasinghe ... Srikantan S Nagarajan
    Event-based sequencing models for Alzheimer’s disease progression revealed that abnormal neural synchrony occurs during the earliest preclinical stages of the disease, preceding brain atrophy and cognitive decline.
    1. Computational and Systems Biology
    2. Neuroscience

    Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges

    Elliot H Smith, Jyun-you Liou ... John D Rolston
    Large bursts of brain activity in patients with epilepsy are geometrically related to seizure propagation.
    1. Evolutionary Biology

    Retinal oxygen supply shaped the functional evolution of the vertebrate eye

    Christian Damsgaard, Henrik Lauridsen ... Mark Bayley
    Multiple respiratory and vascular mechanisms have recurrently evolved across the vertebrates to alleviate the oxygen diffusion limitations inherent to the morphology of the retina.