1,437 results found
    1. Immunology and Inflammation

    Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

    Paul E Chappell et al.
    The number of different peptides presented by major histocompatibility complex class I molecules to the immune system's T lymphocytes is inversely correlated with cell surface expression and is strongly associated with the response to infectious disease.
    1. Immunology and Inflammation

    Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy

    Alok Kumar et al.
    Downregulation of mitochondrial activity by immunosuppressive tumor-derived soluble factors leads to systemic unresponsiveness to the PD-1 blockade therapy.
    1. Cell Biology
    2. Immunology and Inflammation

    TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst

    Clemens Hermann et al.
    We reveal TAPBPR is a peptide exchange catalyst which restricts the peptide repertoire presented by MHC I on cells, a finding which has important implications for all aspects of immune recognition.
    1. Cell Biology
    2. Immunology and Inflammation

    TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway

    Andreas Neerincx et al.
    The recently discovered peptide editor TAPBPR binds to UDP-glucose:glycoprotein glucosyltransferase 1 to provide quality control in the antigen presentation pathway by facilitating the reglucosylation of the glycan on MHC class I molecules.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

    Lina Sagert et al.
    A dedicated structural element facilitates chaperone and antigenic peptide selector function of TAP-associated glycoprotein, a major quality assurance auditor in adaptive immunity.
    1. Immunology and Inflammation

    Functionally diverse human T cells recognize non-microbial antigens presented by MR1

    Marco Lepore et al.
    MR1T cells are human polyclonal T cells endowed with diverse effector functions in response to endogenous antigens presented by MHC-class 1-related molecule, MR1.
    1. Cancer Biology
    2. Immunology and Inflammation

    The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

    Alison Caldwell et al.
    A recently discovered contagious cancer in the Tasmanian devil has the potential to become widespread in the population due to the loss of histocompatibility antigens that are allogeneic to its hosts.
    1. Immunology and Inflammation

    TAPBPR mediates peptide dissociation from MHC class I using a leucine lever

    F Tudor Ilca et al.
    Immunopeptidomics in combination with novel cell-based assays that assess peptide exchange reveal a critical role for the K22-D35 loop of TAPBPR in mediating peptide dissociation and peptide selection on MHC I.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster

    Hyun Bong Park et al.
    A new type of hybrid nonribosomal peptide synthetase (NRPS)-like-pteridine synthase biosynthetic pathway has been illuminated via genome mining.
    1. Immunology and Inflammation
    2. Neuroscience

    Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration

    Melissa A Lopes Pinheiro et al.
    Antigen-specific control of CD4+ T cell trans-migration by brain endothelial cells via presentation of CNS-derived antigens in MHC-II molecules.

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