Real-time imaging of neural activity in behaving mice reveals that the two canonical types of neurons in the olfactory tubercle carry distinct information about learned odor cues, with D1 neurons representing stimulus valence and D2 neurons mainly representing stimulus identity.

Notch signaling regulates the neuroblast intrinsic temporal program to determine when neuroblasts terminate their cell divisions during development.

Absolute quantification of CTCF and cohesin reveals quantitative constraints on 3D genome organization and illuminates the molecular architecture of the cohesin complex.

The effective higher-order binding cooperativities arising from an ensemble of dynamically interchanging conformations are identified and shown to fully describe integration of binding information at thermodynamic equilibrium.

Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.

TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.

Human liver organoids provide a patient-derived platform to interrogate host and viral mechanisms of HBV replication, perform anti-HBV and toxicity drug screens, and investigate the molecular determinants of related tumorigenesis.

A physiological mathematical model of chronic myeloid leukemia, validated by experiments in transgenic mice and clinical data, identifies mechanisms underlying the response to tyrosine kinase inhibitor therapy, predicts biomarkers of primary resistance, and suggests new strategies to improve treatment outcomes.