Caroline Tizian, Annette Lahmann ... Christian Neumann
c-Maf is a novel key regulator of the type 3-to-1 conversion of CCR6– ILC3s that controls the functional plasticity of ILC3s by acting as a cell-intrinsic gatekeeper of T-bet expression.
p21-activated kinase 3 (PAK3) is a factor related to radiation-induced cognitive decline, and it has been found that regulating it leads to the recovery of cognitive decline induced by radiation.
Gene manipulation combined with behavior analysis reveals a role of miR-9 in modulating basal-ganglia-dependent developmental vocal learning and adult vocal performance via regulating the FOXP1/FOXP2 gene network and dopamine signaling in songbirds.
miR-17~92 family of miRNAs control the balance between pro- and anti-inflammatory cytokines in adipose tissue macrophages, the absence of which leads to disturbed adipose homeostasis.
Karthickeyan Chella Krishnan, Elie-Julien El Hachem ... Aldons J Lusis
The discovery of three distinct and independent trans-regulating genomic loci influencing heart mass using a well-characterized mouse reference population provides evidence in support of the hypothesis that genetic diversity in the mitochondrial proteome plays a critical role in heart pathophysiology.
Autoantibodies from myasthenia gravis patients bind a common core region on the nicotinic acetylcholine receptor through a largely conserved mechanism.