5,529 results found
    1. Cancer Biology
    Reproducibility Project

    Reproducibility Project: Cancer Biology

    Edited by Roger J Davis et al.
    Investigating reproducibility in preclinical cancer research.
    1. Ecology
    2. Evolutionary Biology
    The Natural History of Model Organisms

    The Natural History of Model Organisms

    Edited by Ian Baldwin et al.
    Essays on the wild lives of model organisms, from Arabidopsis to the zebrafish.
    1. Structural Biology and Molecular Biophysics

    Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

    Yihe Huang et al.
    High-resolution structures of human TRPM2 in different functional states provided the mechanism underlying ligand recognition, channel activation and inhibition.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

    Axelle Marchant et al.
    Regulatory evolution allows paralogs to escape from strucural pleiotropy.
    1. Structural Biology and Molecular Biophysics

    PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy

    Sergey Gorelick et al.
    The PIE-scope resolves the limitations in correlative cryo-focused ion beam milling by adding robustness and ease of use to the workflow.
    1. Neuroscience

    Possible magneto-mechanical and magneto-thermal mechanisms of ion channel activation in magnetogenetics

    Mladen Barbic
    Several new magneto-mechanical and magneto-thermal mechanisms of ion channel activation in magnetogenetics are proposed that may explain some of the mysteries that challenge current understanding of the magnetogenetics experiments.
    1. Human Biology and Medicine
    2. Neuroscience

    Family history of Alzheimer’s disease alters cognition and is modified by medical and genetic factors

    Joshua S Talboom et al.
    An internet-based cohort study of paired associate learning shows that a first-degree family history of dementia is associated with lowered performance, an effect modified by apolipoprotein E genotype and diabetes.
    1. Structural Biology and Molecular Biophysics

    Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

    Lejla Zubcevic et al.
    Ligand-induced two-fold symmetric arrangement in TRPV2 is observed in the native-like nanodisc-reconstituted condition using cryo-electron microscopy.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity

    Wenlei Ye et al.
    TMEM16F shifts its ion selectivity in response to change of intracellular Ca2+, membrane potential and ionic strength.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Response to comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

    Christina Hertel et al.
    We are writing to reply to the comment by Landegren et al., 2019 about our study (Meyer et al., 2016) on disease-ameliorating autoantibodies.

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