miR-335-3p, which targets FOS and inhibits its activation of NFATC1 signaling, is an important regulator for osteoclast function and responsible for the psychological stress-induced osteoporosis.
Malat1 is a key skeletal regulator, unveiling how lncRNAs integrate cellular crosstalk and molecular networks to regulate bone remodeling and regeneration, establishing a novel paradigm in tissue homeostasis and repair.
Downregulation of PTBP1 in neurons, but not astrocytes, alleviates motor symptoms in a Parkinson’s disease mouse model by inducing dopaminergic marker expression in striatal neurons and increasing striatal dopamine levels.
Analysis of genome-wide spatial transcriptomics data reveals cell-type specific subcellular RNA localization, and a subset of genes show significantly high correlation between spatial patterning and 3' UTR length.
Mir802 serves as a pivotal mediator facilitating communication between adipose tissue and macrophages through the activation of NF-KB signaling pathways.
Integrated ecological and genetic methods show that Bursicon signaling pathway and miR-6012 regulate the transition from summer-form to winter-form in Cacopsylla chinensis through affecting cuticle pigment and cuticle thickness.
