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    1. Developmental Biology
    2. Evolutionary Biology

    Domestic chickens activate a piRNA defense against avian leukosis virus

    Yu Huining Sun, Li Huitong Xie ... Xin Zhiguo Li
    To protect the germ line genome, chickens acquire new small RNA-based immune defense in response to recently endogenized retroviruses by turning a truncated provirus into a weapon.
    1. Neuroscience
    2. Microbiology and Infectious Disease

    Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice

    Roman M Stilling, Gerard M Moloney ... John F Cryan
    Social-interaction impairment in germ-free mice is associated with a markedly altered transcriptional response to social novelty in the amygdala, as characterised by replacement of upregulation of common stimulus-induced pathways with upregulation of the splicing machinery.
    1. Biochemistry and Chemical Biology

    Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

    Prateeka Borar, Tapan Biswas ... Smarajit Polley
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Solid
    1. Evolutionary Biology
    2. Genetics and Genomics

    Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations

    Tim A Crombie, Stefan Zdraljevic ... Erik C Andersen
    Hawaiian Caenorhabditis elegans harbor high levels of genetic diversity that might represent the complex patterns of ancestral diversity in the species prior to human influence.
    1. Medicine
    2. Microbiology and Infectious Disease

    HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity

    Karen Giménez-Orenga, Eva Martín-Martínez ... Elisa Oltra
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Evolutionary Biology

    Seasonal and comparative evidence of adaptive gene expression in mammalian brain size plasticity

    William R Thomas, Troy Richter ... Liliana M Dávalos
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain

    Julio D Perez, Nimrod D Rubinstein ... Catherine Dulac
    A subset of genes in the mouse brain show dynamically regulated and unequal expression of maternally and paternally derived variants, with implications for brain development and function.
    1. Biochemistry and Chemical Biology

    Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

    Hannes Mutschler, Alexander I Taylor ... Philipp Holliger
    Random sequence RNA pools display an innate capacity for ligation and recombination, enabling them to “bootstrap” themselves towards higher compositional, informational and structural complexity.
    1. Developmental Biology
    2. Evolutionary Biology

    An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

    João PL Castro, Michelle N Yancoskie ... Yingguang Frank Chan
    Genome sequencing of mice selected for longer limbs reveals that rapid selection response is due to both discrete loci and polygenic adaptation.