Federico A Vignale, Andrea Hernandez Garcia ... Adrian G Turjanski
DNA sequencing of the yerba mate (Ilex paraguariensis) genome reveals convergent genomic changes, biochemical pathways, mutations, and substrate-binding orientations responsible for caffeine biosynthesis when compared to coffee and tea plants.
Downregulation of PTBP1 in neurons, but not astrocytes, alleviates motor symptoms in a Parkinson’s disease mouse model by inducing dopaminergic marker expression in striatal neurons and increasing striatal dopamine levels.
Analysis of genome-wide spatial transcriptomics data reveals cell-type specific subcellular RNA localization, and a subset of genes show significantly high correlation between spatial patterning and 3' UTR length.
Mir802 serves as a pivotal mediator facilitating communication between adipose tissue and macrophages through the activation of NF-KB signaling pathways.
Integrated ecological and genetic methods show that Bursicon signaling pathway and miR-6012 regulate the transition from summer-form to winter-form in Cacopsylla chinensis through affecting cuticle pigment and cuticle thickness.
For mRNA decapping by enhancing DCP2's mRNA-binding affinity and regulating distinct biological processes through DCP1a and DCP1b, human DCP1 is essential.
Thi Mong Quynh Pham, Thanh Nhan Nguyen ... Le Son Tran
The integration of pHLA binding and pHLA-TCR analysis effectively improves the precision of insilico neoantigen prioritization, potentially enhancing personalized immunotherapies for colorectal cancer.
A multi-disciplined approach uncovered microRNA-199a/b-5p as important regulators of chondrogenesis, which negatively regulate mRNAs such as FZD6, ITGA3, and CAV1 for protective purposes during chondrogenesis.
