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    1. Cell Biology
    2. Chromosomes and Gene Expression

    Reduced expression of C/EBPβ-LIP extends health and lifespan in mice

    Christine Müller et al.
    Reduced expression of a single transcription factor is sufficient to improve fitness and health at old age and increases the lifespan in female mice.
    1. Plant Biology

    Regulation of rice root development by a retrotransposon acting as a microRNA sponge

    Jungnam Cho, Jerzy Paszkowski
    Retrotransposon-derived messenger RNA plays a critical role in rice root development via sequestration of miR171, which suggests a novel trans-acting regulation by transposable elements.
    1. Neuroscience

    Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment

    Cemre Celen et al.
    Mirroring human patients with ARID1B mutations, Arid1b haploinsufficient mice exhibited numerous neuropsychiatric defects and revealed IGF1 deficiency related growth impairment that could be ameliorated with growth hormone supplementation.
    1. Neuroscience
    2. Microbiology and Infectious Disease

    Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice

    Roman M Stilling et al.
    Social-interaction impairment in germ-free mice is associated with a markedly altered transcriptional response to social novelty in the amygdala, as characterised by replacement of upregulation of common stimulus-induced pathways with upregulation of the splicing machinery.
    1. Cancer Biology

    Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

    Kashyap Dave et al.
    A tumor-specific regulatory region has been identified upstream of the Myc oncogene.
    1. Genetics and Genomics

    Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell

    Eran Mick et al.
    Mitochondrial electron transport chain dysfunction triggers the integrated stress response due to an asparagine deficiency downstream of impaired NADH oxidation in proliferating myoblasts, but not in differentiated myotubes.
    1. Cell Biology

    KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

    Anthony A Ruberto et al.
    Krüppel-like factor 10 coordinates the hepatic circadian transcriptome and protects the liver from the adverse effects of increased sugar consumption.
    1. Plant Biology

    Prioritizing plant defence over growth through WRKY regulation facilitates infestation by non-target herbivores

    Ran Li et al.
    A chewing herbivore induced WRKY transcription factor induces jasmonate-dependent defences and supresses gibbererellin-dependent growth, the latter of which renders rice plants more susceptible to secondary infestation by a piercing-sucking herbivore.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A variant-centric perspective on geographic patterns of human allele frequency variation

    Arjun Biddanda et al.
    New tools for visualizing population genetic data can provide a more direct understanding of levels of differentiation among human populations.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice

    Shrestha Ghosh et al.
    The dramatic extension of lifespan in Sirt6-deficient mice by Trp53 haploinsufficiency suggests that SIRT6 has distinct biological function from SIRT1 in regulating p53 activity and preventing cells from senescence/apoptosis.