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    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Identification of key yeast species and microbe–microbe interactions impacting larval growth of Drosophila in the wild

    Ayumi Mure, Yuki Sugiura ... Yukako Hattori
    The growth of wild Drosophila larvae on fruits is promoted by a yeast releasing essential nutrients extracellularly or by a stable association with a nutrient-providing bacterium established by microbe–microbe interactions.
    1. Medicine

    Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms

    Rebecca C Schugar, Christy M Gliniak ... Jonathan Mark Brown
    Small molecule inhibitors of gut microbial choline trimethylamine lyase activity protect against obesity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A model symbiosis reveals a role for sheathed-flagellum rotation in the release of immunogenic lipopolysaccharide

    Caitlin A Brennan, Jason R Hunt ... Edward G Ruby
    Both beneficial and pathogenic bacteria can use their sheathed flagella during host colonization as a novel toxin-/signal-delivery mechanism.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The human gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs

    Leah Guthrie, Sarah Wolfson, Libusha Kelly
    A network of the gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs and supports the generation of mechanistic hypotheses of microbiome metabolic phenotypes that shape human biology.
    1. Medicine

    Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice

    Robert N Helsley, Tatsunori Miyata ... Jonathan Mark Brown
    The gut microbe-derived metabolite trimethylamine (TMA) is elevated in patients with alcohol-associated hepatitis and inhibition of the gut microbial enzymes that produce TMA may serve as a tractable therapeutic strategy for the treatment of ethanol-induced liver injury.
    1. Ecology
    2. Evolutionary Biology

    Reconstructing the functions of endosymbiotic Mollicutes in fungus-growing ants

    Panagiotis Sapountzis, Mariya Zhukova ... Jacobus J Boomsma
    Domestication of endosymbiotic Mollicutes may have resolved nitrogen-recycling challenges for attine ants and enabled the evolutionary derived leaf-cutting ants to fully exploit their herbivorous niches.
    1. Ecology
    2. Microbiology and Infectious Disease

    Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior

    Caleb N Fischer, Eric P Trautman ... Nichole A Broderick
    Interactions between fungal and bacterial microbiome members alter Drosophila melanogaster's chemical environment, affecting host behavior and survival.
    1. Ecology
    2. Microbiology and Infectious Disease

    Microbiome: Finding common connections

    Ma Francesca M Santiago, Aura Raulo
    Ecological associations among gut bacteria are largely consistent across hosts in a population of wild baboons.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

    István Bartha, Jonathan M Carlson ... Jacques Fellay
    An innovative strategy in genome analysis has generated a detailed description of how pathogens mutate when facing human genetic diversity.
    1. Microbiology and Infectious Disease

    The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health

    Qi Yan Ang, Diana L Alba ... Peter J Turnbaugh
    The gut microbiota of East Asians is distinct, dissociated from body mass, and self-sustains compared to White subjects from the same region, and therein may underpin a key health disparity.