192 results found
    1. Computational and Systems Biology
    2. Evolutionary Biology

    The evolution of adhesiveness as a social adaptation

    Thomas Garcia, Guilhem Doulcier, Silvia De Monte
    Mathematical modeling supports a scenario where cell-cell adhesion gradually evolves through natural selection, leading to the emergence of cohesive aggregates in microbial populations.
    1. Structural Biology and Molecular Biophysics

    Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family

    Stefan Brückner, Rajib Schubert ... Hans-Ulrich Mösch
    Structural, biophysical and physiological analysis reveals how yeast cell surface adhesins evolved to confer self-nonself discrimination in single cells and whole populations.
    1. Genetics and Genomics

    The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae

    Clara Bouyx, Marion Schiavone ... Jean Marie François
    The role of amyloid-β-aggregation sequence and of the various domains in the physiological function of the FLO11-encoded adhesin in the yeast Saccharomyces cerevisiae are disclosed in this report.
    1. Microbiology and Infectious Disease

    Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections

    Marissa Jeme Andersen, ChunKi Fong ... Ana L Flores-Mireles
    The use of liquid-infused catheters results in significant reduction of bladder and catheter colonization, systemic dissemination, and bladder inflammation in a clinically relevant mouse model of CAUTI by targeting host-protein deposition on the urinary catheter.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolution of host-microbe cell adherence by receptor domain shuffling

    EmilyClare P Baker, Ryan Sayegh ... Matthew F Barber
    Rapid evolution and gene conversion of a primate cell surface receptor family blocks recognition by pathogenic bacteria.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pneumococcal genetic variability in age-dependent bacterial carriage

    Philip HC Kremer, Bart Ferwerda ... John A Lees
    Future vaccination strategies in pneumococcal disease should target specific bacterial serotypes for different host age groups.
    1. Ecology
    2. Computational and Systems Biology

    Community-level cohesion without cooperation

    Mikhail Tikhonov
    A model of purely competitive ecological dynamics is shown to be equivalent to adaptive evolution of a single individual, suggesting a new way to formalize the "superorganism" metaphor.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    An internal thioester in a pathogen surface protein mediates covalent host binding

    Miriam Walden, John M Edwards ... Ulrich Schwarz-Linek
    Bacterial-encoded covalent adhesion is a new molecular principle in host-microbe interactions and may play a key role in host colonization by a wide range of Gram-positive bacteria.
    1. Ecology
    2. Physics of Living Systems

    Extreme suction attachment performance from specialised insects living in mountain streams (Diptera: Blephariceridae)

    Victor Kang, Robin T White ... Walter Federle
    Net-winged midge larvae use suction organs covered in spine-like cuticular protrusions to generate powerful attachment on wet and rough surfaces.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural foundation for the role of enterococcal PrgB in conjugation, biofilm formation, and virulence

    Wei-Sheng Sun, Lena Lassinantti ... Ronnie P-A Berntsson
    The enterococcal adhesin PrgB consists of four immunoglobulin-like domains that support the proper function of its polymer adhesin domain.

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