747 results found
    1. Microbiology and Infectious Disease

    Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients

    João L Silva-Filho et al.
    Data exploring host and parasite signatures in the peripheral blood indicate that total parasite biomass is a better predictor of P. vivax-induced host responses and pathogenesis than peripheral parasitemia.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size

    Alessandro Bonfini et al.
    The nutrient composition of food alters both the size of gut epithelial cells and the ability of the stem cell niche to control tissue turnover, resulting in changes in size at the organ level.
    1. Genetics and Genomics
    2. Neuroscience

    The structure of behavioral variation within a genotype

    Zachary Werkhoven et al.
    Multidimensional analysis of data from high-throughput behavioral assays reveals many independent axes of behavioral variation among inbred animals reared in the same environment.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

    Juan Carlos Rengifo-Gonzalez et al.
    The RNA-mediated higher order assembly of TDP-43, a protein associated with neurodegenerative diseases, preserves its solubility by reducing the risk of multivalent interactions between low complexity domains.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Gut bacterial aggregates as living gels

    Brandon H Schlomann, Raghuveer Parthasarathy
    A theory of gut bacterial aggregation produces a cluster size distribution that matches that of several strains observed in zebrafish, suggesting principles generally applicable to the vertebrate gut.
    1. Cell Biology
    2. Neuroscience

    Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome

    Anitha P Govind et al.
    Neuronal activity triggers the dispersal of the Golgi into dendritic Golgi satellites, leading to reshaping of the neuronal surface glycoproteome through processing of glycans to mature, sialic acid-containing forms.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Adaptation and compensation in a bacterial gene regulatory network evolving under antibiotic selection

    Vishwa Patel, Nishad Matange
    Mutations in gene regulatory proteins set the stage for the evolution of antimicrobial resistance by shifting the fitness landscape of resistance-conferring mutations.
    1. Microbiology and Infectious Disease

    A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria

    Sofiene Seef et al.
    First identification of the molecular determinants driving contact-dependent predation in Myxococcus..
    1. Genetics and Genomics

    The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae

    Clara Bouyx et al.
    The role of amyloid-β-aggregation sequence and of the various domains in the physiological function of the FLO11-encoded adhesin in the yeast Saccharomyces cerevisiae are disclosed in this report.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Vaccination induces rapid protection against bacterial pneumonia via training alveolar macrophage in mice

    Hao Gu et al.
    Intranasal immunization of inactivated whole cell of some Gram-negative bacteria induces very rapid and efficient protection against bacterial pulmonary by training alveolar macrophage response, which can be harnessed to design rapid-effecting vaccine against multidrug-resistant bacteria infection.

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