76 results found
    1. Cell Biology
    2. Developmental Biology

    Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

    Andrew Kodani et al.
    To control centriole duplication, centriolar satellite proteins assemble a microcephaly-associated protein complex at the centrosome and activate cyclin-dependent kinase 2.
    1. Cell Biology

    PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN

    Andrew Michael Sydor et al.
    The previously uncharacterized protein PPP1R35 is a novel centriolar luminal protein critical for centriole elongation by acting in a complex with microcephaly protein RTTN.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

    Matthew A Cottee et al.
    Structural analyses of the centriole proteins CPAP and STIL identify domains that are critical for centriole formation and provide a structural explanation for a mutation that causes human microcephaly.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Epidemiological and ecological determinants of Zika virus transmission in an urban setting

    José Lourenço et al.
    An ento-epidemiological model reveals that what made the Zika virus a public health problem in Feira de Santana, Brazil, was a surprisingly high attack rate coupled with a low risk of Microcephaly per challenged pregnancy.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis

    Alisa Atkins et al.
    The structural maintenance of chromosomes complex, SMC5/6, is crucial for brain development and function as it ensures proficient DNA replication in neural progenitor cells prior to chromosome segregation.
    1. Neuroscience

    Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex

    Raphael M Bendriem et al.
    That early cortical neural progenitor divisions strictly require OCLN isoform expression is a paradigm shift in the functional consideration of this protein best known for promoting between-cell barrier functions.
    1. Neuroscience

    Downregulation of ribosome biogenesis during early forebrain development

    Kevin F Chau et al.
    Unbiased transcriptome analyses reveal that neural progenitor cells downregulate protein biosynthetic machinery during early forebrain development, and this fundamental process matches proteomic changes in the adjacent cerebrospinal fluid and is regulated in part by MYC.
    1. Developmental Biology
    2. Neuroscience

    The role of the NMD factor UPF3B in olfactory sensory neurons

    Kun Tan et al.
    The nonsense-mediated RNA decay (NMD) branch-specific factor UPF3B influences olfactory sensory neuron cell populations, the olfactory receptor repertoire, and antimicrobial gene expression.
    1. Stem Cells and Regenerative Medicine

    Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

    Stephanie F Bellmaine et al.
    Small molecule inhibition of stem cell differentiation in vitro provides novel insight into how DYRK1A loss disrupts human nervous system development.
    1. Cell Biology
    2. Developmental Biology

    HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development

    Marisa Connell et al.
    HMMR regulates spindle positioning in neural and other cell types downstream of PLK1 and subsequently affects cortical NuMA-Dynein localization.

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