DYRK1A, a kinase associated with intellectual developmental disorders and organ growth regulation, functions in cell growth by promoting mTORC1 activity.
A new way to treat Zika virus infections could be achieved following the definition of an ion channel function for the M protein within virus particles.
The termination of medulla neuroblasts is specified by the depletion of the neuroepithelium and mediated by apoptosis, differentiation, and gliogenic switch.
The protein hyaluronan-mediated motility receptor interacts with microtubules to enhance their stability and recruits TPX2 to promote microtubule emanation in neurons.
It is shown that the absence of the centrosome protein ninein provokes premature ossification during mouse development, due to a defect in the fusion of precursor cells into syncytial osteoclasts.
Smrithi Prem, Bharati Dev ... Emanuel DiCicco-Bloom
Alterations in mTOR signaling drive similar dysregulations in the critical mid-fetal neurodevelopmental processes of neurite outgrowth and cell migration in two distinct subsets of autism, idiopathic and 16p11.2 deletion.
Unlike mouse embryos, mouse embryonic stem cells are able to use a SAS-6-independent pathway for imperfect centriole biogenesis that is associated with a rich centrosomal milieu and robust PLK4 activity.
