Aberrant ERK/MAPK signaling in cortical pyramidal neurons leads to selective disruption of layer 5 circuit development and generalized changes in neuronal excitability.
The mechanistic origins of distinct brain malformations associated with different substitutions at α-tubulin residue 409 are examined, revealing disruption of neuronal migration and microtubule regulation by XMAP215 that scales from protein to tissue.
Jennifer N Jahncke, Daniel S Miller ... Kevin M Wright
Loss of functional dystroglycan disrupts the formation and function of CCK+/CB1R+ inhibitory synapses in hippocampal CA1, resulting in reduced seizure thresholds in mouse models of dystroglycanopathy.
DCX negatively regulates dynein-mediated retrograde transport through two critical interactions by regulating dynein binding to microtubules and regulating the composition of dynein/dyactin/JIP3 motor complex.
Nydia Tejeda-Munoz, Yagmur Azbazdar ... Edward M De Robertis
The archetypal tumor promoter PMA, which promotes cancer without mutating the DNA, increases Wnt signaling by activating macropinocytosis and membrane trafficking in Xenopus embryos and tumor cells.
Clément Mazeaud, Stefan Pfister ... Laurent Chatel-Chaix
Through interactions with viral RNA and NS5, Zika virus changes the composition of the IGF2BP2-containing ribonucleoprotein complex for the benefit of the viral RNA amplification step of its life cycle.
Steven M Markus, Matthew G Marzo, Richard J McKenney
The role of LIS1 in dynein-mediated transport in various biological contexts is reviewed with a focus on recent studies that revealed a new mechanism by which LIS1 functions.
Kelsey H Elliott, Xiaoting Chen ... Samantha A Brugmann
Context-dependent optimization of Gli-binding site occupancy, in the presence of Hand2, is critical for modulating tissue-specific transcriptional output within tissues that lack an obvious Hedgehog morphogen gradient.
