153 results found
    1. Neuroscience

    Automatic discovery of cell types and microcircuitry from neural connectomics

    Eric Jonas, Konrad Kording
    An algorithm for analysing brain connectivity data identifies cell types and connections in simple (C. elegans) and complex (mouse) nervous systems, and can even resolve structure and connectivity in a man-made microprocessor.
    1. Neuroscience

    High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp

    Yangfan Peng et al.
    Combining a multineuron patch-clamp system with an automated pipette pressure and cleaning device enables efficient screening of synaptic connectivity in human brain slices and allows inter-individual comparison.
    1. Neuroscience

    Wiring variations that enable and constrain neural computation in a sensory microcircuit

    William F Tobin et al.
    Systematic and coordinated variations in morphology and connectivity can structurally tune a microcircuit's computation but non-systematic variably also exists, imparting "connection noise" that potentially limits processing performance.
    1. Neuroscience

    Aberrant sorting of hippocampal complex pyramidal cells in type I lissencephaly alters topological innervation

    James A D'Amour et al.
    The loss of lamination in mammalian brain structures under cellular heterotopia carries with it non-uniform ramifications for the various components of the canonical CA1 microcircuitry.
    1. Neuroscience

    Quantitative properties of a feedback circuit predict frequency-dependent pattern separation

    Oliver Braganza et al.
    The feedback inhibitory microcircuit of the dentate gyrus likely boosts pattern separation during gamma oscillations.
    1. Neuroscience

    Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex

    Stephanie C Seeman et al.
    A high-throughput pipeline for the characterization of cortical connectivity in mouse and human cortex.
    1. Neuroscience

    Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion

    Steven Knafo et al.
    Bioluminescence monitoring and selective silencing in zebrafish larva reveal a novel sensorimotor circuit modulating speed in the moving spinal cord.
    1. Neuroscience

    The inhibitory microcircuit of the substantia nigra provides feedback gain control of the basal ganglia output

    Jennifer Brown et al.
    Negative feedback signals within the substantia nigra regulate the output of the basal ganglia, with implications for disorders such as Parkinson's disease.
    1. Neuroscience

    Distinct spatiotemporal mechanisms underlie extra-classical receptive field modulation in macaque V1 microcircuits

    Christopher A Henry et al.
    The multiple component mechanisms of extra-classical receptive field modulation, with distinct dynamics, discovered in the monkey visual cortex have important implications for understanding contextual perceptual processing.
    1. Neuroscience

    Spinal microcircuits comprising dI3 interneurons are necessary for motor functional recovery following spinal cord transection

    Tuan V Bui et al.
    A genetically-defined population of spinal interneurons is reciprocally connected with spinal locomotor circuits and mediates recovery of locomotor function following spinal cord transection.

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