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872 results found
    1. Structural Biology and Molecular Biophysics

    Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

    Dari Kimanius et al.
    Using GPUs for the costly computations in cryo-EM enables structure determination in mere days on a single workstation.
    1. Structural Biology and Molecular Biophysics

    New tools for automated high-resolution cryo-EM structure determination in RELION-3

    Jasenko Zivanov et al.
    RELION-3 calculates single-particle reconstructions to higher resolution and with less user-interactions than previously available versions.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants

    Maria Maldonado et al.
    The structures of plant CIII2, CIV, and SC III2+IV challenge long-standing assumptions, generate new mechanistic hypotheses and allow for the generation of more selective agricultural inhibitors.
    1. Neuroscience

    Evolution of neuronal anatomy and circuitry in two highly divergent nematode species

    Ray L Hong et al.
    The substrate for evolutionary divergence does not lie in changes in neuronal cell number or targeting, but rather in sensory perception and synaptic partner choice within invariant, prepatterned neuronal processes.
    1. Structural Biology and Molecular Biophysics

    Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase

    Maria E Falzone et al.
    Structures of a TMEM16 phospholipid scramblase reveal that its Ca2+-dependent activation entails global conformational changes and how these rearrangements affect the membrane to enable transbilayer lipid transfer.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs

    Michelle S Reid et al.
    The structure of the potassium-chloride cotransporter KCC4 provides insight into the basis of ion specificity, transport stoichiometry, and activity regulation for a broadly physiologically and clinically important transporter family.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

    Juraj Ahel et al.
    RNF213 is a giant E3 ligase with a dynein-like core and a unique ubiquitination mechanism that proceeds in a RING-independent manner and is linked with the Moyamoya disease.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs

    David M Kern et al.
    The basis for small-molecule block, insights into gating, and an unexpected architectural role for the lipid membrane are revealed in structures of the volume regulated anion channel LRRC8A.
    1. Plant Biology

    Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions

    Manuela Kramer et al.
    The regulatory switch from protection to assimilation, which plants use to exploit natural, fluctuating light, involves movement of the enzyme ferredoxin:NADP(H) oxidoreductase between chloroplast membrane complexes.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

    Ricardo Guerrero-Ferreira et al.
    Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.

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