773 results found
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

    David R Hill, Sha Huang ... Jason R Spence
    Contact with bacteria and subsequent hypoxia promotes functional maturation of the immature gastrointestinal tract.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption

    John R Jimah, Nichole D Salinas ... Niraj H Tolia
    The structure, function and mechanism of the malaria vaccine candidate CelTOS reveal a unique pore-forming and membrane-disrupting protein with specificity for the inner leaflet of host and vector cells.
    1. Developmental Biology
    2. Evolutionary Biology

    Par protein localization during the early development of Mnemiopsis leidyi suggests different modes of epithelial organization in the metazoa

    Miguel Salinas-Saavedra, Mark Q Martindale
    Even though the ctenophore Mnemiopsis leidyi develops polarized epithelial tissues, polarization is not mediated by the conserved mechanisms polarizing bilaterian and cnidarian epithelial cells.
    1. Neuroscience

    Transient acidosis while retrieving a fear-related memory enhances its lability

    Jianyang Du, Margaret P Price ... Michael J Welsh
    Activating ASIC channels in the amygdala makes a single reminder more effective at rendering consolidated fear memories labile and susceptible to modification.
    1. Neuroscience

    Inhibition of itch by neurokinin 1 receptor (Tacr1) -expressing ON cells in the rostral ventromedial medulla in mice

    Taylor Follansbee, Dan Domocos ... Earl Carstens
    Activation of Tacr1-expressing neurons including ON cells in the rostral ventromedial medulla inhibits acute and chronic itch-related behavior.
    1. Neuroscience

    Mediodorsal thalamus is required for discrete phases of goal-directed behavior in macaques

    Evan Wicker, Janita Turchi ... Patrick A Forcelli
    Transient suppression of activity in the macaque mediodorsal thalamus impairs adjustment of secondary reinforcer values and disrupts appropriate action selection in a reinforcer devaluation task; this profile is distinct from that of amygdala or subregions of orbitofrontal cortex.
    1. Neuroscience

    Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator

    Ryan S Phillips, Hidehiko Koizumi ... Jeffrey C Smith
    The predictive power of a computational model advances understanding of the neuronal and circuit biophysical mechanisms that generate the respiratory rhythm and neural activity patterns in the mammalian brainstem.
    1. Cancer Biology
    2. Developmental Biology

    The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis

    Nydia Tejeda-Munoz, Yagmur Azbazdar ... Edward M De Robertis
    The archetypal tumor promoter PMA, which promotes cancer without mutating the DNA, increases Wnt signaling by activating macropinocytosis and membrane trafficking in Xenopus embryos and tumor cells.
    1. Immunology and Inflammation
    2. Neuroscience

    Drainage of inflammatory macromolecules from the brain to periphery targets the liver for macrophage infiltration

    Linlin Yang, Jessica A Jiménez ... Celia E Shiau
    Circulation of molecules from the brain can serve as a rapid mode of communication from the brain to the liver.
    1. Developmental Biology
    2. Genetics and Genomics

    Biallelic variants in MAD2L1BP (p31comet) cause female infertility characterized by oocyte maturation arrest

    Lingli Huang, Wenqing Li ... Jianqiang Bao
    Biallelic MAD2L1BP variants contribute to oocyte metaphase I arrest in women with primary infertility and p31comet is required for human oocyte maturation.

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