26 results found
    1. Developmental Biology

    SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate

    Hugo Ducuing et al.
    A combination of in vivo models and imaging techniques reveals the distribution of guidance cues and their mechanisms of action during commissural axon navigation of intermediate target.
    1. Cell Biology

    Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes

    Natalia Wesolowska et al.
    Combined light and electron microscopy reveals a new function for Arp2/3-mediated actin assembly in nuclear envelope rupture, which leads to a separation of nuclear membranes and pores from the lamina.
    1. Cell Biology
    2. Developmental Biology

    HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development

    Marisa Connell et al.
    HMMR regulates spindle positioning in neural and other cell types downstream of PLK1 and subsequently affects cortical NuMA-Dynein localization.
    1. Cancer Biology

    Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

    Patricia L Theard et al.
    Combined EGFR and SOS1 inhibition synergize to inhibit NSCLC spheroid growth.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo

    Kai Xie et al.
    An implantable device based on organic electrochemical transistors is developed for quantitative mapping of neurotransmitter release across multiple brain regions, revealing a cross-talk between the mesolimbic and nigrostriatal dopaminergic pathways.
    1. Cell Biology
    2. Physics of Living Systems

    Myosin II isoforms play distinct roles in adherens junction biogenesis

    Mélina L Heuzé et al.
    Myosin isoforms exhibit different functions in the formation of adherens junctions and the transmission of mechanical forces.
    1. Neuroscience

    Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity

    William D Constance et al.
    Axonal arborisation growth is regulated by dynamic, focal localisations of Neurexin and Neuroligin that provide stability for filopodia, enabling a 'stick and grow'-based mechanism, wholly independent of synapse formation.
    1. Cell Biology
    2. Computational and Systems Biology

    A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes

    Olga Loza et al.
    Localized feedback on Fa4-Ds1 boundary complexes underlies polarized distribution of Fat4 and Ds1 and gives rise to planar cell polarity.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Epithelial geometry regulates spindle orientation and progenitor fate during formation of the mammalian epidermis

    Kimberly Box et al.
    Early in mammalian epidermal development, basal epidermal progenitor cells utilize packing and three-dimensional geometry, rather than cortical polarity cues, to inform division orientation and progenitor cell fate.
    1. Cell Biology

    Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion

    Julia Damiano-Guercio et al.
    Ena/VASP proteins act as positive regulators of cell motility and are required for the formation of microspikes, as opposed to filopodia that can arise from distinct molecular mechanisms.

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