11 results found
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Cluster size determines morphology of transcription factories in human cells

    Massimiliano Semeraro, Giuseppe Negro ... Davide Marenduzzo
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Physics of Living Systems

    Local volume concentration, packing domains, and scaling properties of chromatin

    Marcelo A Carignano, Martin Kroeger ... Igal Szleifer
    The Self Returning Excluded Volume model is the first heuristic, stochastic chromatin model that reproduce single cell and ensemble based experiments bridging nucleosome and chromosome scales.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    OpenNucleome for high-resolution nuclear structural and dynamical modeling

    Zhuohan Lao, Kartik D Kamat ... Bin Zhang
    An open-source tool for computational simulations of the human genome has been introduced, enabling the characterization of complex nuclear environments and the interpretation of experimental observations.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Microphase Separation Produces Interfacial Environment within Diblock Biomolecular Condensates

    Andrew P. Latham, Longchen Zhu ... Bin Zhang
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Explicit ion modeling predicts physicochemical interactions for chromatin organization

    Xingcheng Lin, Bin Zhang
    The physicochemical interactions among wild-type nucleosomes hold substantial significance and play a role in chromatin folding under physiological salt concentrations.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Protein compactness and interaction valency define the architecture of a biomolecular condensate across scales

    Anton A Polyansky, Laura D Gallego ... Bojan Zagrovic
    A colloid fractal cluster model provides a quantitative link between the atomistic features of an intrinsically disordered polypeptide and the spatial organization of the biomolecular condensate it forms.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Regulation of chromatin microphase separation by binding of protein complexes

    Omar Adame-Arana, Gaurav Bajpai ... Samuel Safran
    Chromatin-binding proteins regulate the effective solvent quality experienced by chromatin and impact global chromatin organization in the nucleus.
    1. Physics of Living Systems

    How enzymatic activity is involved in chromatin organization

    Rakesh Das, Takahiro Sakaue ... Tetsuya Hiraiwa
    Computer simulations considering actions of the intranuclear enzyme, Topoisomerase-II, in a mechanistic scheme elucidated a capability of enzymes to contribute to controlling chromatin spatial organizations and discovered new characteristic features in eu- and heterochromatin organization caused by the enzymatic activity.
    1. Biochemistry and Chemical Biology

    Membrane-partitioned cell wall synthesis in mycobacteria

    Alam García-Heredia, Takehiro Kado ... M Sloan Siegrist
    Mycobacteria employ plasma membrane compartments to organize their cell wall synthesis, and the finalized cell wall compartmentalizes the plasma membrane to promote an environment conducive to its own synthesis.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Dynamic metastable long-living droplets formed by sticker-spacer proteins

    Srivastav Ranganathan, Eugene I Shakhnovich
    Multi-scale simulations reveal a potential, ATP-independent mechanism resulting in the formation of the long-living multi-droplet state by multi-valent, spacer-sticker proteins.

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