4,759 results found
    1. Cell Biology

    Male meiotic spindle features that efficiently segregate paired and lagging chromosomes

    Gunar Fabig et al.
    Chromosome segregation in male spermatocytes exhibits anaphase A without shortening of autosome-associated microtubules and partitioning of an unpaired X chromosome that is initiated by an imbalance of attached kinetochore microtubules.
    1. Neuroscience

    Spatiotemporal patterns of neocortical activity around hippocampal sharp-wave ripples

    J Karimi Abadchi et al.
    The hippocampus and neocortex engage in waves of mutual excitation wherein a sharp wave-ripple may occur at any time before, during or after the peak of the hippocampal-neocortical activation.
    1. Neuroscience

    Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour

    Judit García-González et al.
    Zebrafish studies are able to predict loci and biological pathways affecting human behaviour, paving the way to better understanding of the biological underpinnings of psychiatric disease.
    1. Developmental Biology

    An abundant quiescent stem cell population in Drosophila Malpighian tubules protects principal cells from kidney stones

    Chenhui Wang, Allan C Spradling
    Drosophila renal stem cells are exceptional in abundance, require induction to produce a single cell type, principal cells, and mitigate damage during adulthood associated with external stresses.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration

    Konstantinos Sousounis et al.
    Experimental manipulation of a core DNA damage response factor and cell-cycle checkpoint regulators reveals a key role for these processes in the progenitor cells that fuel limb regeneration.
    1. Physics of Living Systems

    Sperm chemotaxis is driven by the slope of the chemoattractant concentration field

    Héctor Vicente Ramírez-Gómez et al.
    The slope of the chemoattractant concentration gradient is a driving force for sperm chemotaxis, by coordinating the entrainment of information flow between sensing, signaling and motility.
    1. Immunology and Inflammation

    Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

    Marisa Stebegg et al.
    Older individuals have impaired conventional dendritic cell and T follicular helper cell formation upon vaccination, which can be rescued by treatment with a TLR7 agonist.
    1. Cell Biology
    2. Neuroscience

    Site-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs

    Zora Chui-Kuen Chan et al.
    Postsynaptic MT1-MMP serves as a molecular switch to synaptogenesis by clearing the surrounding ECM environment that allows effective deposition of nerve-derived synaptogenic factors to induce postsynaptic differentiation at developing NMJs.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    The transpeptidase PBP2 governs initial localization and activity of the major cell-wall synthesis machinery in E. coli

    Gizem Özbaykal et al.
    For initiation of cell-wall insertion, the cross-linking enzyme PBP2 stably binds to a component of the cell envelope that is different from MreB filaments.
    1. Genetics and Genomics

    Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity

    Nicholas Sciascia et al.
    Analysis of genome integrity in primary murine B-cells reveals how depleting 26S proteasome activity enhanced cell survival following treatment with topoisomerase poisons.

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