668 results found
    1. Cell Biology
    2. Ecology

    Ubiquitous macropinocytosis in anthozoans

    Philippe Ganot et al.
    Macropinocytosis, the process of non-specific endocytosis, is a major gateway for large volumes of surrounding medium and nanoparticles to coral cells.
    1. Cell Biology
    2. Neuroscience

    Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory

    Junjun Zhao et al.
    Two homologous kinesin motors, KIF5A and KIF5B, have distinct functions in dendritic spine morphogenesis, and KIF5B plays a role in synaptic plasticity and memory.
    1. Cell Biology
    2. Neuroscience

    TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons

    Emily Bowie, Sarah C Goetz
    Signaling at the primary cilium is important to sustain the morphology, connectivity, and survival of a key neural population within the brain.
    1. Cell Biology

    Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes

    Natalia Wesolowska et al.
    Combined light and electron microscopy reveals a new function for Arp2/3-mediated actin assembly in nuclear envelope rupture, which leads to a separation of nuclear membranes and pores from the lamina.
    1. Genetics and Genomics

    Loss of centromere function drives karyotype evolution in closely related Malassezia species

    Sundar Ram Sankaranarayanan et al.
    The centromeres in Malassezia species, by breakage or inactivation, facilitate genome rearrangements that can result in varying karyotypes and contribute to the evolution of these species.
    1. Cell Biology
    2. Neuroscience

    Ser/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating microtubule-microtubule sliding

    Rosalind Norkett et al.
    Microtubule-microtubule sliding and neurite outgrowth in Drosophila is controlled by a Ser/Thr kinase Tricornered via phosphorylation of a 'mitotic' motor protein Pavarotti.
    1. Neuroscience

    Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation

    Marc D Tambini et al.
    APP mutations that either cause or prevent dementia alter APP metabolism in a complex and opposite fashion, suggesting a link between multiple APP processing events, dementia and ageing-dependent cognitive decline.
    1. Structural Biology and Molecular Biophysics

    Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

    Lan Wang et al.
    Msp1 recruits substrates at the open seam of the spiral oligomer and extracts them with functionally adapted elements.
    1. Structural Biology and Molecular Biophysics

    Structure of the human BBSome core complex

    Björn Udo Klink et al.
    The structure of the human BBSome explains how the subunits interact with each other and how disease-causing mutations hamper this interaction.

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