4,910 results found
    1. Stem Cells and Regenerative Medicine

    Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut

    Aiguo Tian, Jin Jiang
    The niche signal that ensures stem cells self-renew appropriately has been identified in the midgut of Drosophila.
    1. Stem Cells and Regenerative Medicine

    Physiological and stem cell compartmentalization within the Drosophila midgut

    Alexis Marianes, Allan C Spradling
    The intestine contains distinct subregions specialized for digestion along its anterior-posterior axis, and the stem cells that constantly renew these subregions are not interchangeable.
    1. Cancer Biology
    2. Human Biology and Medicine

    Cancer Therapeutics: Partial loss of genes might open therapeutic window

    Bo Liu, Omar Abdel-Wahab
    The loss of genes that encode RNA splicing factors weakens cancer cells in a way that could be exploited by new approaches to treatment.
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    1. Microbiology and Infectious Disease

    Foot and Mouth Disease: Virus-resistant pigs might help to stem next outbreak

    Lisbeth Ramirez-Carvajal, Luis L Rodriguez
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    1. Stem Cells and Regenerative Medicine

    Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

    Yunyun Jin et al.
    The Brahma chromatin remodelling complex interacts with the Hippo signalling pathway to regulate the proliferation and differentiation of stem cells in the Drosophila midgut.
    1. Developmental Biology

    Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut

    Erez Cohen et al.
    Ploidy-increasing endocycles may represent a tradeoff between loss of regenerative capacity and preservation of tissue architecture.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut

    Chiwei Xu et al.
    In response to tissue damage, reactive oxygen species can be sensed by cation channels TRPA1/RyR to cause increases of cytosolic Ca2+ in intestinal stem cells, activating Ras/MAPK activity and stimulating stem cell proliferation in Drosophila.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Epidemiology: Promiscuous bacteria have staying power

    Ruth C Massey, Daniel J Wilson
    Being able to take up DNA from their environment might allow pneumococcal bacteria to colonize the human nose and throat for longer periods of time.
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