1,620 results found
    1. Developmental Biology

    Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation

    Rieko Asai, Vivek N Prakash ... Takashi Mikawa
    At the onset of gastrulation, primitive streak morphogenesis that requires mitosis along the embryo midline, persists even with a disrupted bilateral cell flow.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Genetic variation of putative myokine signaling is dominated by biological sex and sex hormones

    Leandro M Velez, Cassandra Van ... Marcus M Seldin
    Genetic architecture of muscle secreted protein functions are dominated by sex.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Midkine is a dual regulator of wound epidermis development and inflammation during the initiation of limb regeneration

    Stephanie L Tsai, Clara Baselga-Garriga, Douglas A Melton
    Elucidation of the molecular basis of early wound epidermis dependence during salamander limb regeneration reveals midkine as a key modulator of wound epidermis development and wound-healing resolution.
    1. Cell Biology

    Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B

    Manuel Lera-Ramirez, François J Nédélec, Phong T Tran
    A simple mechanism relying on microtubule rescues occurring at midzone edges allows fission yeast spindles to elongate during anaphase B while maintaining microtubule overlaps, without the need to precisely regulate microtubule growth speed.
    1. Developmental Biology
    2. Neuroscience

    Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion

    Karina Chaudhari, Madhavi Gorla ... Greg J Bashaw
    Axon repulsion in response to the midline repellent slit depends on an evolutionary conserved interaction between the Roundabout receptor and the wave regulatory complex.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Two locus inheritance of non-syndromic midline craniosynostosis via rare SMAD6 and common BMP2 alleles

    Andrew T Timberlake, Jungmin Choi ... Richard P Lifton
    Epistatic interactions of rare loss of function mutations in SMAD6 and a common variant modifier near BMP2 are the most common cause of midline craniosynostosis in humans.
    1. Medicine
    2. Neuroscience

    The need to change: Is there a critical role of midlife adaptation in mental health later in life?

    Friederike Thams, Stefanie Brassen
    A new developmental model of cognitive-emotional adaptation in midlife builds on current findings from lifespan psychology, cognitive neuroscience, and research in late-life depression.
    1. Developmental Biology

    Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly

    Joshua Bloomekatz, Reena Singh ... Deborah Yelon
    Studies in zebrafish and mouse implicate the PDGF signaling pathway in the communication between the endoderm and the myocardium that drives medial myocardial movement and thereby initiates cardiac morphogenesis.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

    Jay F Sarthy, Michael P Meers ... Steven Henikoff
    Deposition of mutant oncohistones by alternative nucleosome assembly pathways results in dramatic local differences in histone methylation in pediatric diffuse midline gliomas.
    1. Developmental Biology
    2. Neuroscience

    Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

    Timothy A Evans, Celine Santiago ... Greg J Bashaw
    The Roundabout2 receptor acts non-autonomously to promote commissural axons to cross the midline by antagonizing Slit-dependent axon repulsion.

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